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  • Articles: DFG German National Licenses  (3)
  • Lamb shift  (1)
  • Monoclonal antibody  (1)
  • PACS 25.43.+t Antiproton-induced reactions – 24.60.Dr Statistical compound nucleus reactions – 24.75.+i General properties of fission  (1)
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  • Articles: DFG German National Licenses  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Gonadal steroid receptors in meningiomas (1987)
    Springer
    Journal of neurology 234 (1987), S. 328-333 
    Details
    ISSN: 1432-1459
    Keywords: Oestrogen receptor ; Progesterone receptor ; Androgen receptor ; Monoclonal antibody ; Meningioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oestrogen receptor (ER) analysis was performed in 70 meningiomas with an enzyme immunoassay, using monoclonal antibodies against human oestrogen receptor protein (oestrophilin) and with a sensitive radioligand binding assay, using 125I-oestradiol as radioligand. Low levels of ER immunoreactivity were found in tumours from 51% of patients, whereas ER binding activity was demonstrated in 40% of the meningiomas examined. In 8 (11%) tissue samples multiple binding sites for oestradiol were observed. The immunoreactive binding sites corresponded to the classical, high-affinity ER. In ligand binding studies, however, measurement of classical ER was considerably influenced by a second low-affinity, high-capacity oestrogen binding component even at low ligand concentrations. 3H-methylpromegestone and 3H-methyltrienolone, a synthetic gestagen and androgen, were used for concurrent determination of the progesterone receptor (PR) and androgen receptor (AR) binding activity. High concentrations of PR were detected in 53 (76%), whereas moderate levels of AR binding sites were demonstrated in 33 (47%) tumours. A positive correlation between ER immunoreactivity and AR binding activity is indicative for an oestrogen regulation of AR via the ER system. The presence of gonadal steroid receptors in a large proportion of meningiomas and the tendency for a dependence of receptor concentrations on the histological subtype could have implications for tumour therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314289
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neutrons produced by 1.22 GeV antiproton interactions with nuclei (2000)
    Springer
    The European physical journal 8 (2000), S. 197-204 
    Details
    ISSN: 1434-601X
    Keywords: PACS 25.43.+t Antiproton-induced reactions – 24.60.Dr Statistical compound nucleus reactions – 24.75.+i General properties of fission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: Inclusive neutron energy spectra were measured by time of flight using 1.22 GeV antiprotons from LEAR, CERN, as projectiles and targets from natural Al, Cu, Ag, Ho, Ta, Au, Pb, Bi, U. The sum of two Maxwellian distributions was fitted to the spectra obtained at several forward and backward angles yielding neutron multiplicities Mi and slope or temperature parameters T i for the low-energy (evaporative, i=1) and high-energy (pre-equilibrium,i=2) parts, respectively. M 1 increases with A, proportional to the nuclear volume, and M 2 is growing with A , proportional to the nuclear radius. The T parameters are nearly independent of A. The results are compared with previous multiplicity measurements with a neutron detector, intranuclear cascade calculations and neutron spectra from stopped antiproton annihilation on nuclei. With the measured proton spectra also the ratio of emitted neutrons to protons was determined for Au.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100500070106
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experiment to measure the Lamb shift in muonic hydrogen (2000)
    Springer
    Hyperfine interactions 127 (2000), S. 161-166 
    Details
    ISSN: 1572-9540
    Keywords: proton ; proton radius ; muon ; muonic hydrogen ; Lamb shift
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The contribution of the root mean square (RMS) proton charge radius to the Lamb shift (2S–2P energy difference) in muonic hydrogen (μp) amounts to 2%. Apart from the uncertainty on this charge radius, theory predicts the Lamb shift with a precision on the ppm level. We are going to measure ΔE (2 S1/2(F=1)–2 P3/2(F=2)) in a laser resonance experiment to a precision of 30 ppm (i.e., 10% of the natural linewidth) and to deduce the RMS proton charge radius with 10−3 relative accuracy, 20 times more precise than presently known. The most important requirement for the feasibility of such an experiment, namely the availability of a sufficient amount of long lived metastable μp atoms in the 2S state, has been investigated in a recent experiment at PSI. Our analysis shows that in the order of one percent of all muons stopped in low pressure hydrogen gas form a long lived μp(2S) with a lifetime of the order of 1 μs. The technical realization of our experiment involves a new high intensity low energy muon beam, an efficient low energy muon entrance detector, a randomly triggered 3 stage laser system providing the 0.5 mJ, 7 ns laser pulses at 6.02 μm wavelength, and a combination of a xenon gas proportional scintillation chamber (GPSC) and a microstrip gas chamber (MSGC) with a CsI coated surface to detect the 2 keV X rays from theμp(2P → 1S) transition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012679114531
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    Paper (German National Licenses)
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