ISSN:
1434-9949
Keywords:
Hypertension
;
Nephroangiosclerosis
;
Thrombotic Microangiopathy
;
Lupus Anticoagulant
;
Anticardiolipin Antibody
;
Primary Antiphospholipid Syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We describe two patients with the primary antiphospholipid syndrome who presented with severe hypertension. Renal biopsy specimen provided histologic evidence of intra-renal vascular disease with intravascular microthrombosis and nephrosclerosis, without feature of proliferative glomerulopathy. Accelerated hypertension and nephroangiosclerosis might indeed be one of the complications associated with anticardiolipin antibodies. The mechanism responsible might be the intereaction of anticardiolipin antibodies, platelets and endothelial cell leading to microthrombi formation and increased local mitogenic activity that attract and stimulate neighbouring smooth muscle cell and fibroblast proliferation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02243009
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