ISSN:
1435-1463
Keywords:
Forebrain ischaemia
;
gerbil
;
glycine b antagonists
;
MRZ 2/570
;
MRZ 2/576
;
NBQX
;
hippocampus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Novel antagonists of the glycineB site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min. global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neurones in the CA1 region, which was prevented by NBQX, and reduced to 50% by both glycineB antagonists. NBQX produced a delayed, long lasting (up to 24 hr) hypothermia while hypothermia with both glycineB antagonists was transient.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01294724
Permalink