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  • Articles: DFG German National Licenses  (2)
  • Magnetic Resonance Imaging  (1)
  • healthy volunteers  (1)
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  • Articles: DFG German National Licenses  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    MR evaluation of the parotid gland using STIR and Gadolinium-enhanced imaging (1992)
    Springer
    European radiology 2 (1992), S. 357-364 
    Details
    ISSN: 1432-1084
    Keywords: Salivary gland ; Magnetic Resonance Imaging ; Gadolinium-DTPA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to determine the efficiency of the STIR sequence in teh pre-operative assessment of salivary gland lesions, and to evaluate whether administration of intravenous contrast medium provided any additonal information. Nineteen patients with presumed parotid lesions were imaged using T1-weighted soin-echo and STIR sequences and nine patients also had Gadolinium-DTPA (Gd-DTPA) enhancement. The pathological nature of all lesions was confirmed by cytological or histological examination. T1-weighted spin-echo images were most useful for visualising anatomical structures and identifying the course of the facial nerve. Internal strcuture of tumours was best displayed with gladolinium enhanced images. Margination and conspicuity of lesions was optimal with STIR, which also achieved a minimal resolution of lesions of 4 × 6 mm diameter. Gd-DTPA enhancement of small lesions was sometimes misleading as they became obscured by surrounding enhancing glandular tissue or overlying fat. It is concluded that the combination is adequate to display anatomy and pathology with accuracy in both extensive ans subtle salivary gland disease. Gd-DTPA did not add to the diagnostic information already obtained by T1 and STIR imaging despite clearer demonstration of tumour architecture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175442
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Bioavailability of the bis- and monodigitoxosides of digitoxigenin (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 649-652 
    Details
    ISSN: 1432-1041
    Keywords: digitoxigenin ; monodigitoxoside ; bisdigitoxoside ; biovailability ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic behavior of digitoxigenin is affected by the number of glycosides present. This study was conducted to compare the bioavailabilities of the bis- and monodigitoxosides of digitoxigenin in man. Intravenous and oral doses of the two drugs were administered to six normal volunteers. Blood samples were collected up to 28 days after each dose, and assayed for the specific drug administered and for total radioassayable drug. Both drugs were virtually completely absorbed, based on serum concentrations of administered drug plus metabolites. However, the mean bioavailability of unchanged bisdigitoxoside was only 56.3% indicating that substantial metabolism occurred prior to entry into the systemic circulation. Monodigitoxoside was virtually completely metabolized prior to entry into the systemic circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607909
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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