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Digitale Medien

The effect of haloperidol on epinephrine-stimulated adenylate cyclase in humans (1976)

Belmaker, Robert H. ; Ebstein, Richard P. ; Schoenfeld, Helen ; [weitere]

Springer

Psychopharmacology 49 (1976), S. 215-217

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Details

ISSN: 1432-2072

Schlagwort(e): Lithium ; Haloperidol ; Epinephrine ; Adenylate cyclase ; Mania

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Administration of epinephrine in man has been shown previously to lead to a rise in plasma cyclic AMP levels by activation of the β-adrenergic-stimulated adenylate cyclase. Therapeutic doses of lithium in humans block the epinephrine-induced rise in plasma cyclic AMP levels, suggesting that lithium inhibits β-adrenergic adenylate cyclase. In contrast, ten subjects receiving haloperidol, a drug also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals. These findings are discussed in relation to the possible pharmacological mechanisms of action of lithium and haloperidol in the control of mania.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00427293

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