Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (2)
  • Matrix effects  (1)
  • desethylamiodarone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Proficiency testing schemes for therapeutics and toxicology (2000)
    Springer
    Accreditation and quality assurance 5 (2000), S. 389-391 
    Details
    ISSN: 1432-0517
    Keywords: Key words Proficiency testing ; Matrix effects ; Therapeutic drug monitoring ; Toxicology acceptance criteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  This report addresses the proposition: current proficiency testing (PT) schemes for therapeutics and toxicology can easily engender complacency. The proposition was based on the premise that there are substantial between-laboratory differences and objectives in the supply of services for the measurement of drugs, as a result of which it is difficult to design PT schemes which adequately cover the requirements of all laboratories. Thus, acceptable performance in a PT scheme may lead participants to consider that they have tested their procedures more rigorously than is the case. Four areas, validity of the PT scheme, PT material, frequency of testing and acceptance criteria are examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690000194
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The digoxin-amiodarone interaction (1989)
    Springer
    Cardiovascular drugs and therapy 3 (1989), S. 25-28 
    Details
    ISSN: 1573-7241
    Keywords: digoxin ; amiodarone ; desethylamiodarone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To assess the cause of the digoxin-amiodarone interaction, the systemic availability and renal excretion of digoxin were examined in 10 patients. Patients were studied before and after 1 week and 6 weeks of concurrent amiodarone therapy, and four were also studied after 4–8 months. Mean (±SD) peak plasma digoxin concentration rose from 1.55±0.6 μg/l prior to amiodarone therapy to 2.85±1.3 μg/l after 1 week of combined therapy (p〈0.01). Mean AUC also rose from 7.2±2.1 μg/l.h to 12.1±6.4 μg/l.h (p〈0.01) during this period. Mean peak plasma digoxin concentration and AUC remained elevated after 6 weeks and, in the patients studied, at 4–8 months. Mean urinary digoxin clearance remained unchanged. Plasma amiodarone and desethylamiodarone concentrations were consistent with the prescribed doses. This study confirmed previous findings of raised plasma digoxin concentrations following the addition of amiodarone. It has also shown that this interaction is sustained for at least several months. The cause has not been fully elucidated but does not appear to be due to a change in the renal clearance of digoxin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01881526
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...