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  • Artikel: DFG Deutsche Nationallizenzen  (3)
  • Middle ear effusion  (1)
  • Middle ear fluid  (1)
  • Protease inhibitors  (1)
Datenquelle
  • Artikel: DFG Deutsche Nationallizenzen  (3)
Materialart
Erscheinungszeitraum
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  • 1
    Digitale Medien
    Digitale Medien
    The relationship between antigen levels and middle ear inflammation in antigen-induced otitis media in the chinchilla (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 42-46 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Antigen-induced otitis media ; Human serum albumin ; Middle ear effusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The relationship between antigen levels in middle ear effusions (MEE) and the degree of middle ear inflammation was studied in an antigen-induced otitis media model, using chinchillas sensitized with human serum albumin (HSA). The degree of middle ear inflammation was evaluated by both tympanometric analysis, and cytological and biochemical analyses of the MEE. Middle ear inflammation develops after HSA challenge with a remarkable decrease in HSA levels in the MEE. This inflammation persists even when HSA levels are no longer detectable in the MEE. These findings show that local challenges with an antigen induce a certain degree of middle ear inflammation, which continues even after complete elimination of the antigen from the middle ear through an immunological defense mechanism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00463547
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Vascular permeability of the middle ear mucosa in otitis media with effusion (1987)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 218-221 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Otitis media with effusion ; Protease inhibitors ; Vascular permeability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Vascular permeability (VP) of the middle ear mucosa (MEM) in chronic otitis media with effusion (OME) was estimated in both pediatric and adult patients by calculating the middle ear effusion (MEE) to serum concentration ratios of albumin and of four protease inhibitors: α1-antitrypsin (α1-AT), α1-antichymotrypsin (α1-X), inter-α-trypsin inhibitor (I-α-I) and α2-macroglobulin (α2-M). The levels of albumin and α1-AT in MEE were higher while those of I-α-I and α2-M were lower than their serum levels in both adult serous and pediatric mucoid groups. There was a negative correlation between molecular weight and the mean value of the ratio (MEE/serum) of the four inhibitors in both serous (r=−0.989) and mucoid (r=−0.924) groups. Vascular permeability of the MEM seems to be variable in both serous and mucoid groups during middle ear inflammation. Selective leakage of proteins by molecular weight appears to occur in MEM. Our findings further indicate that a high level of the high-molecular-weight inhibitor α2-M in MEE may be a significant index reflecting the remarkably enhanced VP of the MEM.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00455309
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Biochemical and cytological studies of immune-complex-induced otitis media in the chinchilla (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 77-81 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Immune complex ; Middle ear fluid ; Otitis media
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pathogenesis of immune complex (IC)-induced otitis media in the chinchilla was studied through cytological and biochemical analyses of middle ear fluid (MEF) recovered after instillation of premade IC. The number to total leukocytes was 3.03±2.13×106/cm3, and mainly involved neutrophils (72.3%) and macrophages (22.7%). The mean value of total protein, α1-antitrypsin (α1-AT) and α2-macroglobulin (α2-M) was 27.1mg/ml, 189.5 and 75.2mg/dl. The number of leukocytes had a significant correlation with the levels of total protein, α1-AT and α2-M (P〈0.01). The inflammatory reaction induced by premade IC is characterized by an increased vascular leakage and an infiltration of leukocytes into the locus. The percentage of macrophages in the total leukocytes was larger in IC-induced otitis media than that in antigen-induced otitis media. These findings suggest that cellular events in the early stage of IC-induced otitis media may be different from antigen-induced otitis media.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00481440
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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