ISSN:
1573-6830
Keywords:
AT2 receptor
;
growth curve
;
cell–cell contact
;
angiotensin converting enzyme
;
NIH3T3 fibroblasts
;
neoplastic transformation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract 1. A high expression of angiotensin II receptors and of angiotensin-converting enzyme (ACE) activity was detected in confluent NIH 3T3 fibroblasts. 2. Characterization with selective ligands, dithiothreitol, and GTPγS, indicated that only the AT2 subtype was expressed. 3. AT2 receptors and ACE expression were strictly dependent on the cell density and growth phase of the cells, with AT2 receptors being expressed earlier than ACE. In contrast, high expression of AT2 receptors irrespective of their growth state was observed in NIH 3T3 cells lacking contact inhibition upon neoplastic transformation with ras. 4. Our results imply a possible relation of AT2 receptors to cell growth and cell–cell contact.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006985329240
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