Electronic Resource
Springer
Journal of cancer research and clinical oncology
110 (1985), S. 48-50
ISSN:
1432-1335
Keywords:
Non-renal excretion
;
Methotrexate
;
Cholestyramine binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The anion exchange resin cholestyramine binds methotrexate (MTX) effectively in vitro. The binding capacity exceeds that of activated charcoal by a factor of 5.4. On two patients undergoing high-dose MTX therapy it is also shown that cholestyramine binds MTX in vivo. This leads to an enhanced non-renal excretion of MTX. Therefore, cholestyramine may be of clinical value in patients who develop renal function impairment whilst undergoing MTX therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00402501
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