ISSN:
1573-2592
Keywords:
Human antibody responses
;
influenza virus
;
monoclonal antibody
;
OKT4 antibody
;
T cells
;
T-cell subsets
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Studies were undertaken to define the helper T-cell requirements forin vitro specific antibody production to influenza virus. Subpopulations of human T cells were separated on the basis of their reactivity with the monoclonal antibody OKT4. B cells cultured with OKT4+ T cells produced specific antibody to influenza virus, while B cells cultured with OKT4− T cells did not. Irradiation (1200 rads) of the OKT4− subset to potentially eliminate suppressor-cell activity did not augment the helper-cell function of that subset. Thus, unlike the cytotoxic T-cell response to influenza, help for anin vitro antibody response is mediated only by OKT4+ T cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00916895
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