ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H-NMR spectrum of Boc-(L-Val-D-Val)4-OH in CDCl3 can be attributed either to an antiparallel or to a parallel double-stranded β5.6-helical structure. To resolve this ambiguity, T1-measurements have been carried out for the α-protons of Boc-(L-Val-D-Val)4-OH and its monodeuterated analogue Boc-(L-Val-D-Val)2 -α-2H-L-Val-D-Val-L-Val-D -Val-L-Val-D-Val-OH. The results show that the Hα of the fifth residue in one strand is close to the Hα of the seventh residue in the other strand, as expected for an antiparallel arrangement, a conclusive demonstration that the correct structure of Boc-(L-Val-D-Val)4-OH is antiparallel.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19830660723
Permalink