ISSN:
1432-2307
Keywords:
αl-antitrypsin
;
αl-antichymotrypsin
;
Salivary gland
;
Pleomorphic adenoma
;
Immunohistochemistry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Immunohistochemical identification of αl-antitrypsin (αl-AT) and αl-antichymotrypsin (αl-ACh) in pleomorphic adenomas of salivary glands is reported in order to compare their distribution profiles with those of lysozyme and lactoferrin, already described elsewhere. Normal salivary glands indicated positive αl-AT staining in ductal segments and had no αl-ACh in any glandular cell. Pleomorphic adenomas displayed moderate positivity to αl-AT staining in duct-like, tubular and glandular epithelia which was particularly intense in luminal cells. The limited number of tumour cells which showed duct-like structures with a single cellular layer arrangement, displayed the highest staining to αl-ACh. Strongly αl-AT positive tumour cells located on the inner side of luminal cavities were also markedly positive to αl-ACh. Spindle shaped tumour cells existed outside tubular and ductal structures and were negative to αl-AT and αl-ACh. Distribution of αl-AT in salivary glands was similar to that of lysozyme as is usual in ductal segments or their transformed cells, and occurrence of αl-ACh localization rather resembled that of lactoferrin, with occurrence in acinar compartments and changed epithelia within acini. The biological role of a specific immunohistochemical distribution of αl-AT and αl-ACh in pleomorphic adenomas may be associated with a self regulating mechanism which inhibits degradation by tissue proteinases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00707975
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