ISSN:
1438-2199
Keywords:
Keywords: Amino acids
;
Growth hormone
;
Spinal cord injury
;
Edema formation
;
Spinal cord evoked potentials
;
Spinal cord edema
;
Cell injury
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. The influence of exogenous rat growth hormone on spinal cord injury induced alterations in spinal cord evoked potentials (SCEP) and edema formation was examined in a rat model. Repeated topical application of rat growth hormone (20 μl of 1 μg/ml solution) applied 30 min before injuryand at 0 min (at the time of injury), 10 min, 30 min, 60 min, 120 min, 180 min, and 240 min, resulted in a marked preservation of SCEP amplitude after injury. In addition, the treated traumatised cord showed significantly less edema and cell changes. These observations suggest that growth hormone has the capacity to improve spinal cord conduction and attenuate edema formation and cell injury in the cord indicating a potential therapeutic implication of this peptide in spinal cord injuries.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007260070067
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