ISSN:
1572-8854
Keywords:
Steroids
;
pregnadiene
;
hydroxyprednisolone acetals
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract The crystal and molecular structures of two synthetic corticosteroid diastereoisomers were determined by X-ray diffraction methods. (22R)-21-acetoxy-16α,17α-furfurylidenedioxy-11β-hydroxy-pregna-1,4-diene-3,20-dione, C28H32O8, crystallized in the orthorhombic system, space group P212121,a=6.346(1),b=14.106(2),c=27.901(3) Å, andZ=4. (22S)-21-acetoxy-16α, 17α-furfurylidenedioxy-11β-hydroxy-5 pregna-1,4-diene-3,20-dione ethanolate, C28H32O8 ·C2H5OH, crystallized in the monoclinic system, space group C2,a=20.382(5),b=8.331(1),c=17.346(4)Å, β=103.43(2)°, andZ=4. A change of configuration at the C(22) chirality center has influence on the remote parts of the molecules. The long-range effects appear in the ability to form intermolecular hydrogen bonds by different atoms and consequently in the solvation of the (S) diastereoisomer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01665975
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