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  • Artikel: DFG Deutsche Nationallizenzen  (2)
  • Traceability  (1)
  • digoxin  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Delivering quality for the measurement of immunosuppressive drugs: current performance and future needs (1999)
    Springer
    Accreditation and quality assurance 4 (1999), S. 427-430 
    Details
    ISSN: 1432-0517
    Schlagwort(e): Key words Drugs proficiency testing ; Analytical quality indicators ; Calibrator material ; Traceability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract  Whilst it is generally agreed that measurement of immunosuppressive drugs is of value as a guide to therapy, there are a number of problems associated with the analytical techniques available. Proficiency testing schemes enable laboratories to judge their performance for the measurement of these drugs with their peers. However, current schemes only compare accuracy within-methods to document performance. This paper summarizes current findings and points out the limitations of our own schemes, and the measures we intend to use to address these deficiencies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s007690050402
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 2
    Digitale Medien
    Digitale Medien
    The digoxin-amiodarone interaction (1989)
    Springer
    Cardiovascular drugs and therapy 3 (1989), S. 25-28 
    Details
    ISSN: 1573-7241
    Schlagwort(e): digoxin ; amiodarone ; desethylamiodarone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To assess the cause of the digoxin-amiodarone interaction, the systemic availability and renal excretion of digoxin were examined in 10 patients. Patients were studied before and after 1 week and 6 weeks of concurrent amiodarone therapy, and four were also studied after 4–8 months. Mean (±SD) peak plasma digoxin concentration rose from 1.55±0.6 μg/l prior to amiodarone therapy to 2.85±1.3 μg/l after 1 week of combined therapy (p〈0.01). Mean AUC also rose from 7.2±2.1 μg/l.h to 12.1±6.4 μg/l.h (p〈0.01) during this period. Mean peak plasma digoxin concentration and AUC remained elevated after 6 weeks and, in the patients studied, at 4–8 months. Mean urinary digoxin clearance remained unchanged. Plasma amiodarone and desethylamiodarone concentrations were consistent with the prescribed doses. This study confirmed previous findings of raised plasma digoxin concentrations following the addition of amiodarone. It has also shown that this interaction is sustained for at least several months. The cause has not been fully elucidated but does not appear to be due to a change in the renal clearance of digoxin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01881526
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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