ISSN:
1572-8773
Keywords:
Ca 2+ /calmodulin-dependent protein kinase IV
;
calcium
;
calmodulin
;
CREB
;
T lymphocyte
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Ca 2+ /calmodulin dependent protein kinase IV (CaMKIV) is a multifunctional, serine-threonine protein kinase that is activated in the presence of increased intracellular calcium ( Ca 2+ ).CaMKIV is a potent medi-ator of Ca 2+ induced gene expression, primarily through its ability to phosphorylate and activate transcrip-tion factors such as CREB. CaMKIV-dependent activation of CREB is a key event in the expression of genes involved in the processes of T-cell activation and neuronal long term potentiation. The focus of this review is to describe the biochemical regulation of CaMKIV and examine how CaMKIV activates tran-scription in response to calcium in both cell and animal models.© Kluwer Academic Publishers
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009276932076
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