ISSN:
1573-3904
Keywords:
combinatorial chemistry
;
MHC
;
peptidomimetics
;
solid-phase synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract New ligands for major histocompatibility complex (MHC) class I molecules were prepared using a flexible automated synthesis of oligocarbamates. An efficient solution-phase synthesis was found for Fmoc-amino alcohols which are required as building blocks. The biological activity of the oligomeric peptidomimetics was demonstrated in a stabilizing assay with MHC class I presenting cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008821817913
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