ISSN:
1572-8927
Keywords:
Aqueous solubility
;
octanol-water partition coefficient
;
activity coefficient
;
n-propylbenzene
;
ethylbenzene
;
n-hexane
;
di-isopropyl ether
;
chloroform
;
nitrobenzene
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract From thermodynamics and certain assumptions it is shown that, under the usual experimental conditions, the octanol-water partition coefficient (Ko/w) of a given organic liquid should be the same whether the substance is partitioned neat or as part of a mixture. Measurements of several mixtures of n-propylbenzene (log Ko/w=3.71±0.04)+ethylbenzene (log Ko/w=3.16±0.01) clearly confirm this. It is also shown that the aqueous solubility (Sw) of a neat organic liquid can be related to its aqueous solubility (S w ′ ), when it is present at volume fraction ϕ in an organic liquid mixture, by S w ′ =γϕSw, where γ is its activity coefficient in the organic mixture. The measured S w ′ values for n-propylbenzene + ethylbenzene (γ≈1), n-hexane + nitrobenzene (γ〉1) and di-isopropyl ether + chloroform (γ〈1) are found to be in good agreement with the predicted values (average differences of, respectively, 〈2%, ≈8% and ≈6%). In general, the bounds on S w ′ are expected to be 0〈S w ′ 〈Sw.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00649042
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