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Comparison of pregnancy rates following in vitro fertilization—embryo transfer between the donors and the recipients in a donor oocyte program (1992)

Check, Jerome H. ; Nowroozi, Kosrow ; Chase, Jeffrey ; [et al.]

Springer

Journal of assisted reproduction and genetics 9 (1992), S. 248-250

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ISSN: 1573-7330

Keywords: donor oocyte ; recipients ; hyperstimulation regimen ; pregnancy rates

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Our in vitro fertilization (IVF) program provides a unique opportunity to evaluate influences of hormonal milieu on pregnancy outcome, by using a shared pool of oocytes obtained by donors (in exchange for financial assistance). The study presented herein evaluated 38 retrieval cycles (28 oocyte donors/22 recipients). No difference in mean number of embryos transferred was seen (2.7 in the donors vs 2.8 in the recipients). However, a statistically significant difference was seen in the pregnancy rates per retrieval (10.5% donors vs 29% recipients) and per transfer (4/35, 11.1%, vs 11/34, 32.3%). Abortion rates were similar (25% donor, 27.2% recipients). These data suggest that other reports of higher pregnancy rates from donor oocyte programs may not be due exclusively to better-quality oocytes. Possibly a negative effect of hyperstimulation or adverse endometrial environment of the donor (possible chronic endometritis) may explain these data.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01203822

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The effect of the age of the recipients on pregnancy rates following donor-oocyte replacement (1993)

Check, Jerome H. ; Ali Askari, H. ; Choe, Jung ; [et al.]

Springer

Journal of assisted reproduction and genetics 10 (1993), S. 137-140

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ISSN: 1573-7330

Keywords: aging ; endometrial thickness ; oocyte recipients ; pregnancy rates

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Results The pregnancy rate was considerably lower, 8.5% in recipients in ovarian failure who were ⩾ 40 years old (n =23) compared to younger recipients, 〈40 years of age (n =55), who were also in ovarian failure, which would support the uterine senescence theory.

Abstract: Conclusion The endometrial factor may be manifested by failure to generate a critical endometrial thickness of 10 mm by sonography in 61% of the older group, compared to only 29% of the younger group. Future studies should address methods of improving the endometrial thickness in the older group, to determine if improved pregnancy rates will occur and to evaluate whether increasing luteal support with extra progesterone may also improve pregnancy rates.

Notes: Purpose Besides waning ovarian function with advancing age, the question of a uterine senescence factor has been proposed as a cause of decreased fecundity. The replacement of oocytes from younger donors into older recipients allows further investigation into the aging endometrium.