ISSN:
1573-6903
Keywords:
GABAA Receptor
;
pregnane steroids
;
Benzodiazepines
;
chloride channel
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Conclusion Based on the pharmacological and biochemical evidence to date, especially that derived from the recombinantly expressed receptor studies, the suggestion that a novel GBRC-linked steroid recognition site exists becomes a cogent argument. The high affinity of the steroid site for certain naturally occurring metabolites of progesterone and glucocorticoids favors a physiologic role for these steroids in the regulation of brain excitability. Clearly, investigations of such a regulatory role is warranted. If present, it provides an important example of endocrine control of a major inhibitory neurotransmitter in the CNS. Moreover, as we gain a greater understanding of the molecular organization of the GBRC, the putative steroid site provides a novel target for the rational design of therapeutic agents for the treatment of anxiety, epilepsy, and insomnia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00966098
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