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Digitale Medien

In vitro assessment of the haemolytic potential of candidate drugs (1994)

Salauze, D. ; Decouvelaere, D.

Springer

Comparative clinical pathology 4 (1994), S. 34-36

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Details

ISSN: 1433-2981

Schlagwort(e): Haemolytic potential ; In vitro ; Whole blood

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Several chemicals cause haemolysis when administered to mammals by the intravenous route. From a regulatory point of view there are no recommended methods for assessing the haemolytic potential of candidate drugs. In our laboratory, we routinely investigate the reaction between human (or animal) whole blood and candidate drugs (or their vehicles or metabolites) and measure haemolysis by assaying haemoglobin in the supernatants. Here, we describe this method. This test is inexpensive and requires only few millilitres of whole blood.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00368264

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