ISSN:
1573-2568
Keywords:
GERANYLGERANYLACETONE
;
GASTRIC MUCOSAL CELL
;
APOPTOSIS
;
HEAT-SHOCK PROTEINS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The purpose of this study was to elucidate themolecular mechanism of action of geranylgeranylacetone,an antiulcer drug. Treatment with ethanol for 8 hr atthe optimum concentration (7.5%) caused apoptotic DNA fragmentation in cultured guinea piggastric mucosal cells. Pretreatment of cells withgeranylgeranylacetone suppressed the DNA fragmentationin a dose-dependent manner. The maximum effect wasachieved at 10-6 M, at which concentration the drug waspreviously shown to induce heat-shock proteins. Thesuppression required an incubation period longer than 1hr. Pretreatment of cells with low concentrations of ethanol also prevented DNAfragmentation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026692920848
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