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  • Artikel: DFG Deutsche Nationallizenzen  (8)
  • 1
    Digitale Medien
    Digitale Medien
    Crossreactivity of IgE antibody against Dermatophagoides farinae with Limulus polyphemus agglutinin (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Crossreactivity of IgE antibody against Dermatophagoides farinae (Der f) with Limulus polyphemus agglutinin (LPA) was examined using RAST and immunoblot analysis. Of 40 Der f-sensitive asthmatic patients, 28 revealed a positive RAST reaction to LPA, while none of 20 Der f-insensitive hay fever patients showed this reaction. LPA-specific RAST levels of the 40 asthmatic patients correlated with their Der f-specific levels. The RAST reactivity to LPA was competitively inhibited by the addition of either soluble Der f or LPA, but not by the specific inhibitory sugar of sialic acid. LPA could also induce histamine release from leucocytes of Der f-sensitive asthmatic patients. IgE immunoblot analyses showed that the positive RAST sera for LPA had a strong IgE binding activity to the 30 kDa and 80 kDa components of DER F body extract, whereas gel filtration studies showed that the high molecular weight fractions above 150 kDa retained antigenic constituents associated with IgE reactivity to LPA. These results suggest that the antigenic materials of Dermatophagoides mites share some determinants with the haemagglutinin of horseshoe crabs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00252.x
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  • 2
    Digitale Medien
    Digitale Medien
    Comparisons of IgE, IgG, and IgG4 responsiveness to Dermatophagoides farinae in children by immunobulotting (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Although asthmatic children are often sensitized to the house-dust mite (HDM) during early childhood, it is not clear what antigenic components are associated with the early immune response of these children. To investigate this problem, we evaluated IgE, IgG, and IgG4 antibody responses to Dermatophagoides farinae (Df) by immunoblotting among three groups of children: group I aged 0–4 years, group II aged 5–9 years, and group III aged 10–14 years. In the group I subjects, positive IgE-binding reactions to 15– and 25-kDa components were found in 76% and 44% of sera, respectively. Those to other components were generally low in frequency. In contrast, positive IgG-binding reactions to 15– and 25-kDa components were found in 44% and 24% of sera, and those to 30– and 110-kDa components in 48% and 88% of sera, respectively. Positive IgG4 reactions to 15– and 25-kDa components were found in 48% and 24%, respectively, and those to other components were very low. Positive IgE-binding reactions to these components gradually became more frequent with increasing age in groups II and III, while IgG and IgG4 reactivities were not markedly different in these age groups. These results suggest that the 15-and 25-kDa proteins of Df are important antigens associated with the initial IgE response to HDM in early childhood, while the 30– and 110-kDa proteins are associated with IgG and 15-kDa components with IgG4.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04491.x
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  • 3
    Digitale Medien
    Digitale Medien
    Separate Regulation of Heme Oxygenase and Heat Shock Protein 70 mRNA Expression in the Rat Heart by Hemodynamic Stress
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 191 (1993), S. 587-594 
    Details
    ISSN: 0006-291X
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1006/bbrc.1993.1258
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  • 4
    Digitale Medien
    Digitale Medien
    Remodelling of Microvessels by Coronary Hypertension or Cardiac Hypertrophy in Rats
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 26 (1994), S. 49-59 
    Details
    ISSN: 0022-2828
    Schlagwort(e): Collagen ; Coronary circulation ; Hypertension ; Hypertrophy ; Rat studies
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1006/jmcc.1994.1007
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  • 5
    Digitale Medien
    Digitale Medien
    Preferential Expression of HSC70 Heat Shock mRNA in Gerbil Heart After Transient Brain Ischemia
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 25 (1993), S. 1131-1135 
    Details
    ISSN: 0022-2828
    Schlagwort(e): Cerebral ischemia ; Heart ; Heat shock cognate protein
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1006/jmcc.1993.1126
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  • 6
    Digitale Medien
    Digitale Medien
    Effects of Age on c-fos and c-myc Gene Expression in Response to Hemodynamic Stress in Isolated, Perfused Rat Hearts
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 25 (1993), S. 1025-1035 
    Details
    ISSN: 0022-2828
    Schlagwort(e): Aging ; Myocardial hypertrophy ; Proto-Oncogene ; Wall Stress
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1006/jmcc.1993.1115
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  • 7
    Digitale Medien
    Digitale Medien
    Mechanical interaction between the ventricles (1983)
    Springer
    Basic research in cardiology 78 (1983), S. 544-559 
    Details
    ISSN: 1435-1803
    Schlagwort(e): ventricular interaction ; diastolic compliance ; RV overload ; contractility
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We investigated ventricular interaction by the use of six excised, perfused, canine hearts. In this preparation, we could change the filling pressure of the right and left ventricles independently, thereby breaking the normal series-pump arrangement. We found that mechanical ventricular interaction exists in diastole and in systole. Namely, not only decreased diastolic ventricular compliance, but also the reduced performance in either ventricle was found, when the opposite ventricular pressure was increased. Thus, when the opposite ventricular filling pressure increases, we suspect that systolic ventricular function of either ventricle will be depressed significantly by these two factors; i.e., the Frank-Starling effect due to decreased ventricular diastolic volume following decreased diastolic ventricular compliance, and the depressed systolic ventricular function. Clinically, these findings may be important in considering the mechanism of the occurrence of simultaneous reduced performance of both ventricles in cases when only one side of the ventricle is affected hemodynamically and its filling pressure is greatly increased in various pathological states such as heart failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01906465
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  • 8
    Digitale Medien
    Digitale Medien
    Pressure-length loop in the ischemic segment during left circumflex coronary artery stenosis and its modification by afterload reducing in excised perfused canine hearts (1984)
    Springer
    Basic research in cardiology 79 (1984), S. 155-163 
    Details
    ISSN: 1435-1803
    Schlagwort(e): myocardial ischemia ; pressure-length loop ; ischemic regional function ; afterload reducing ; coronary blood flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary By using excised perfused heart preparations, we investigated the regional myocardial functions in the presence of a flow-limiting coronary stenosis of the left circumflex coronary artery (LCX) (approximately a 50% flow reduction of pre-ischemic control), as well as global cardiac functions during afterload reducing, while keeping left ventricular end-diastolic pressure (LVEDP) and heart rate constant. After inducing the LCX stenosis, cardiac output (CO), peak left ventricular pressure (peak LVP) and stroke work (SW) decreased from pre-ischemic control values, i.e., 81.1±3.2%, p〈0.005, 88.1±3.8%, p〈0.02 and 72.2±5.7%, p〈0.005, respectively (n=7), whereas pressure-length (P-L) loop areas changed as follows; ischemic control values of the left anterior descending coronary artery (LAD) and LCX regions were 96.6±6.0%, n.s. and 72.6±9.0% of pre-ischemic control, p〈0.02, respectively. Following afterload reducing with LCX stenosis, CO increased gradually, while the ischemic regional function started to further aggravate, and the initial point of further ischemic aggravation obtained in this experiment occurred at 63.5±6.9 mm Hg of mean aortic pressure (AoP). These results suggested that the increase of total cardiac function such as CO following afterload reducing was probably induced at the expense of aggravated regional ischemia. Therefore it was concluded that the treatment of ischemic myocardium by reducing afterload pressure should be done very carefully.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01908302
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