ISSN:
0894-3230
Keywords:
Organic Chemistry
;
Physical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Reversed-phase HPLC capacity factors, as log k′, have been correlated through the LFER equation: \documentclass{article}\pagestyle{empty}\begin{document}$${\rm log k}^\prime = {\rm c} + {\rm rR}_2 + {\rm s\pi }_2^{\rm H} + {\rm a}\sum {\rm \beta }_2^0 + {\rm vV}_{\rm X}$$\end{document} where k′ is the capacity factor for a series of solutes in a given stationary phase-mobile phase system, and the explanatory variables are the solute descriptors: R2 an excess molar refraction, π2H the dipolarity/polarizability, Σα2H the overall hydrogen-bond acidity, Σβ20 the overall hydrogen-bond basicity and Vx the McGowan volume. This equation was applied to various C18 stationary phases with methanol-water, acetonitrile-water and tetrahydrofuran-water buffered mobile phases. The solute and mobile phase factors that influence log k′ values are set out, and a comparison is made between log k′ values and water-octanol partition coefficients.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/poc.610071205
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