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  • Articles: DFG German National Licenses  (2)
Source
  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 61 (1989), S. 656-660 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2277
    Keywords: Immunosuppression ; local ; islet allografts ; Islet allografts ; FK 506 ; FK 506 ; local ; islet allografts ; Budesonide ; islet allografts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Local delivery of immunosuppressive agents may dampen local alloreactive events with avoidance of systemic toxicity. We investigated the innovative strategy of intraportal (IPO) delivery of three immunosuppressive agents in streptozotocin diabetic rat recipients of islet allografts (Lewis to Wistar-Furth) transplanted intrahepatically. IPO budesonide (BUD, 240 or 360 μg/kg per day), a potent steroid, and cyclosporin (CyA, 2 or 4 mg/kg per day) did not prolong graft mean survival time [MST±standard deviation (SD)] as compared to nonimmunosuppressed recipients. Fourteen days of IPO FK 506 (0.16 mg/kg per day) significantly increased MST as compared with untreated controls (49±29 vs 7±1 days, P〈0.01) and was more effective than intravenous (IV) FK 506 (17±7 days, P〈0.01). When FK 506 was given for 28 days, the benefit of IPO over IV delivery was reaffirmed (MST 81±32 vs 34±4 days, P〈0.01). The potential for toxicity was lessened by lower mean systemic levels in the IPO group as compared to the IV group (1.3±0.6 vs 3.5±0.9 ng/mg, P〈0.02). The strategy of continuous IPO FK 506 was effective in the prevention of rejection of intrahepatic islet allografts.
    Type of Medium: Electronic Resource
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