ISSN:
1420-9071
Keywords:
Adenylate cyclase
;
somatostatin
;
forskolin
;
isoproterenol
;
lymphocytes
;
leukemic cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In normal lymphocytes somatostatin non-competitively inhibited basal (ID50 5×10−4 M) and isoproterenol- and forskolin-stimulated adenylate cyclase activity (Ac). In acute leukemia blasts, non-responsive to isoproterenol, forskolin, which activates the catalytic subunit, stimulated and somatostatin inhibited Ac, thus indicating the leukemic enzyme, though defective, retains the inhibitory pathway and catalyst function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01953315
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