ISSN:
1524-475X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Maththaan thailam, the Datura leaf juice is traditionally used for healing of wounds and related ailments in India. However, the scientific validity of the thailam has not been explored in the literatures. In the present study, the efficacy of maththaan thailam on healing of three types of wounds namely Open, Burn and Diabetic wound in animal models has been studied. Healing pattern and biochemical characterization of granulation tissue were assessed over the healing periods. Studies were more concentrated on to evaluate the change in the matrix metallo proteinase profile in the three different types of wound with respect to the applied thailam. Further supports were also expected from the antioxidant levels and histopathological examination of granulation tissue. It has been observed that among the three types of wounds, delayed healing was observed with diabetic wound. Complete healing of 2 × 2 cm2 wound size was achieved only after 22 days, whereas burn and open wound took only 16 and 9 days for complete closure. Further, MMP’s profile also showed a variation in the expression of MMP2 and MMP9 with respect to healing property. Biochemical and histochemical results and the antioxidant levels are highly correlated with the healing property irrespective of the wounds
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1067-1927.2004.0abstractes.x
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