ISSN:
1432-1440
Keywords:
Human corticotropin-releasing factor (hCRF)
;
C-peptide
;
Naloxone
;
Opioid receptor blockade
;
Type 2 diabetes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Administration of synthetic human corticotropin-releasing factor (hCRF, 2 µg/kg body weight) during simultaneous application of the opioid antagonist naloxone (1.6 mg i.v. bolus, followed by an infusion at a rate of 1.2 mg/h) produced a significant increase in plasma C-peptide levels of six male Type 2 diabetic patients which even exceeded the postprandial values. This stimulatory effect of hCRF/naloxone on plasma C-peptide was less pronounced in six healthy men. hCRF alone did not provoke any reaction of plasma C-peptide in either group. The possibility of a paracrine, CRF-dependent mechanism in pancreatic islets which somehow involves inhibitory opioid receptors is preferentially discussed. Such a mechanism may underlie the stimulatory action of hCRF/naloxone on B cells and would explain the absent reaction of peripheral venous plasma C-peptide to hCRF alone as well as the amplifying effect of simultaneous opioid receptor blockade.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01727787
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