ISSN:
1432-2072
Keywords:
Serotonin uptake inhibitor
;
Serotonin in thrombocytes
;
Ro 11-2465
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Ro 11-2465, a cyanide derivative of imipramine with serotonin uptake inhibitory properties, was investigated in six healthy volunteers for its effect on serotonin concentration in blood platelets. The initial dose was 1 mg daily, the maximum dose of 3 mg being reached on day 3 and maintained for 7 days. A significant decrease in the platelet serotonin concentration was not observed until 3 days after the start of drug administration, after which depletion was rapid. After 5 days of treatment, the reduction was about 80% compared to predrug level. Serotonin restoration after drug withdrawal was very slow, and 5 days after discontinuation, it was still 70% below its baseline level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00431746
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