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  • 1
    Electronic Resource
    Electronic Resource
    Supratentorial primitive neuroectodermal tumor in children: clinical features, treatment outcome and prognostic factors (1999)
    Springer
    Child's nervous system 15 (1999), S. 377-383 
    Details
    ISSN: 1433-0350
    Keywords: Key words Primitive neuroectodermal tumor ; Child ; Prognosis ; Necrosis ; Surgical resection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To investigate clinical features, treatment outcome and prognostic factors of pediatric supratentorial primitive neuroectodermal tumors(ST-PNETs), 28 ST-PNET cases were retrospectively analyzed. The prognostic importance of age, sex, size of tumor, M stage, extent of surgical resection, histological features, immunohistochemical labelling indices (Ki-67, p53), and apoptotic index were assessed. The mean age at diagnosis was 6.8 years, and the male-to-female ratio was 18:10. The presenting symptoms in 22 cases were increased intracranial pressure and focal neurological deficits. Gross total resection was achieved in 17 cases, near-total (〉90%) resection in 3, and subtotal in 7; biopsy was performed in 1 case. The mean duration of follow-up was 37 months. For 25 patients who completed planned adjuvant therapy, the 3-year survival rate was 73%. Univariate analysis showed that the presence of tumor necrosis (P=0.002) and extent of resection (P=0.04) correlated with survival. Patients with a high Ki-67 labelling index (〉10%) tended to have shorter survival (P=0.095). In multivariate analysis, tumor necrosis showed statistical significance(P=0.03).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050418
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  • 2
    Electronic Resource
    Electronic Resource
    Intramedullary anaplastic oligodendroglioma in a child (1998)
    Springer
    Child's nervous system 14 (1998), S. 127-130 
    Details
    ISSN: 1433-0350
    Keywords: Key words Anaplastic oligodendroglioma ; Intramedullary spinal cord tumor ; Children ; Radiation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Primary intramedullary anaplastic oligodendroglioma is a rare tumor, only four cases of which have been reported. The authors present the case of a 38-month-old boy with primary intramedullary anaplastic oligodendroglioma. He underwent partial removal of the tumor and spinal radiation therapy. The residual tumor disappeared 12 months after radiation, and 48 months after treatment there was no evidence of recurrence. This case shows that in primary intramedullary anaplastic oligodendroglioma, postoperative radiation therapy confined to the spinal cord can yield an optimal result.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050194
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A simple method of predicting hormonal outcome in children with intracranial germinoma (1999)
    Springer
    Child's nervous system 15 (1999), S. 179-184 
    Details
    ISSN: 1433-0350
    Keywords: Key words Intracranial germinoma ; Prolactin ; Thyroid function ; Hormonal outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Even a small intracranial germinoma (GE) frequently provokes pituitary hypofunction. We evaluated the relationships between preoperative hormonal status and hormonal outcome and between size of suprasellar mass and hormonal outcome in 22 children with intracranial pure GE to determine whether or not these can reflect the degree of hypothalamo-pituitary axis destruction. Preoperative hormonal status was graded from I to IV according to the serum prolactin level (s-PRL) and thyroid function (TF). The hormonal outcome was estimated by the type and the number of hormonal replacement medications taken on the basis of the triple load test and endocrinological examinations at the time of the last follow-up (median period: 43 months). Fifteen of the 22 patients had suprasellar lesions. All 13 patients who had diabetes insipidus (DI) at presentation needed desmopressin acetate (DDAVP) during the follow-up period. The correlation between increment of preoperative grade and the increment in the number of hormones to be replaced was statistically significant (P〈0.05). This preoperative grading was a more reliable predictor than the size of suprasellar tumor. In conclusion, preoperative grading by s-PRL and TF test is useful for the prediction of posttreatment hormonal replacement in children with intracranial pure GE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050365
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Treatment of intracranial nongerminomatous malignant germ cell tumor in children: the role of each treatment modality (1999)
    Springer
    Child's nervous system 15 (1999), S. 185-191 
    Details
    ISSN: 1433-0350
    Keywords: Key words Nongerminomatous malignant germ cell tumor ; Surgery ; Radiotherapy ; Chemotherapy ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To investigate the role of surgical tumor resection, radiotherapy and chemotherapy, the outcome of treatment in 17 children with nongerminomatous malignant germ cell tumor (NG-MGCT) was reviewed. The median follow-up period was 38 months after diagnosis, and the overall 3-year survival rate was 75%. Eleven patients who underwent craniospinal radiation (CSRT) did not receive chemotherapy. In 4 of them more than 90% of the tumor was removed, and they were free of disease at 16, 30, 93 and 111 months after surgery. Among the other 7, who did not undergo tumor resection (n=5) or had considerable residual tumor (n=2), 2 were disease-free at 73 and 88 months after diagnosis, and 5 died of recurrences. Of 6 patients who received cisplatin and etoposide chemotherapy in addition to CSRT, none showed intracranial recurrence, regardless of the extent of removal. The authors believe that multimodal treatment is the preferred choice and that chemotherapy plays an important role, especially when a significant amount of tumor remains after surgery. CSRT plays a major role at least in some patients. If chemotherapy is not feasible, radical removal plus CSRT seems to be an alternative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050366
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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