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  • Artikel: DFG Deutsche Nationallizenzen  (16)
  • 1
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Monoclonal antibodies against myelin-associated glycoprotein were generated by fusing mouse myeloma cells with spleen lymphocytes from BALB/c mice immunized with human myelin-associated glycoprotein purified from CNS myelin. Three groups of antibodies were identified: IgG antibodies recognizing the polypeptide moiety and IgG and IgM antibodies recognizing the carbohydrate moiety of the intact molecule. Properties of these antibodies were examined with sodium dodecyl sulfate-polyacrylamide gel electrophoresis and the immunostaining technique using human CNS and peripheral nerve myelin, and ganglioside fractions isolated from human brain and peripheral nerve, and with immunohistochemical staining of human peripheral nerves. Part of human peripheral blood mononuclear cells was stained with the antibodies against the carbohydrate moiety, but not with IgG antibodies recognizing the polypeptide moiety. Natural killer activity was partially reduced after treatment of human peripheral blood lymphocytes with an IgM antibody and complement in vitro. The possibility that anti-myelin-associated glycoprotein antibodies might play a role in the pathogenesis of demyelinating diseases through modification of natural killer activity is discussed.
    Materialart: Digitale Medien
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  • 2
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 83 (1979), S. 1306-1309 
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Company
    Nature biotechnology 3 (1985), S. 176-176 
    ISSN: 1546-1696
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: [Auszug] Until recently, biotechnology in Japan was mainly a matter of fermentation—in brewing and the manufacture of pharmaceuticals and organic chemicals. However, recent strides in molecular biology and molecular immunology make us confident that the technology will play a key role in production ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-1912
    Schlagwort(e): Key words Antiandrogen ; Tyrosine hydroxylase ; Catecholamine ; SHR; inbred ; Adrenal medulla ; Blood pressure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We investigated the effects of the antiandrogen flutamide on the activity of tyrosine hydroxylase, the levels of its encoding mRNA, and catecholamine levels in the adrenal medulla of male spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Flutamide (30 mg/kg) was administered subcutaneously daily (between 9 and 15 weeks of age). The systolic blood pressure of flutamide-treated SHR rats was lower than that of control SHR. Epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and the levels of encoding mRNA in the adrenal medulla were significantly lower in flutamide-treated SHR rats than in paired controls. Systolic blood pressure, epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and encoding mRNA in the adrenal medulla of WKY rats showed no significant differences between flutamide-treated and control groups. These findings suggested that flutamide may have cardiovascular effects through alteration of the catecholamine synthetic pathway caused by removal of androgen receptor stimulation on the expression of tyrosine hydroxylase in the adrenal medulla of male SHR rats.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Journal of materials science 19 (1984), S. 2219-2222 
    ISSN: 1573-4803
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract Rapid quenching was applied to the sodium tungsten bronzes, Na x WO3, of differentx values. The crystallization processes of the coloured flakes obtained were analysed by differential thermal analysis and X-ray powder diffraction. It was found that an “amorphous bronze” phase is present in the quenched Na0.71WO3, whereas quenched Na0.84WO3 was composed of tungsten crystal and Na2O-WO3 glass. This difference is explained by the following equilibrium present in the melt of Na x WO3: 3xNa2WO4+(6−4x)WO3+xW⇄6Na x WO3 This equilibrium is shifted to the right whenx is small (x〈0.7), while it is shifted to the left whenx is large (x〉0.8).
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Journal of materials science 17 (1982), S. 3593-3597 
    ISSN: 1573-4803
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract In the systems R2O-WO3 (R=Li, Na, K), the glass-forming region was extended by use of the rapid quenching technique combining a thermal-image furnace with a twin roller. The infra-red spectra revealed that the Li2WO4 glass contains no condensed macro-anions but only discrete ions of Li+ and WO 4 2− . The glass transition temperature (T g) and the crystallization temperature (T c) were determined.T g is affected very slightly by the type of alkali cations, whereas it is decreased with increase in the alkali oxide content. More than oneT g was observed in Li2O-WO3 glasses, which is due to the formation of metastable phases. The conductivity of glasses containing the same amount of alkali oxide (of different types) increased with decrease in the radius of the alkali cation. Electrochromism was observed in the glasses with R=Li, Na; the electric field required for colouration is lower than that in WO3 films. The electro-colouration is due to HxWO3 formed in the glass matrix by the double injection of protons and electrons.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Colloid & polymer science 225 (1968), S. 112-116 
    ISSN: 1435-1536
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die thermische Leitfähigkeit für glasige Natriumphosphate verschiedener Zusammensetzung wurde im Temperaturbereich von 50 bis 160° gemessen. Der Temperaturkoeffizient thermischer Leitfähigkeit nimmt mit dem Anteil anR (Na2O/P2O5 molares Verhältnis) zu und ändert sein Vorzeichen von positiven zum negativen Werten vonR in der Nähe von eins. Im Bereich der Zusammensetzung vonR=0,7 bisR=1,4, indem die thermische Leitfähigkeit mit Zunahme vonR zunimmt, läßt sich die Abhängigkeit von der Zusammensetzung für die thermische Leitfähigkeit durch die Abhängigkeit von Dichte und Kompressibilität von der Zusammensetzung erklären. Das restliche Wasser in den Phosphaten auf der Ultraphosphat-Seite der Zusammensetzung scheint einen großen Einfluß auf die thermische Leitfähigkeit zu haben.
    Notizen: Summary The thermal conductivity was measured for vitreous sodium phosphates of a variety of compositions in the temperature range from 50° to 160°. The temperature coefficient of the thermal conductivity decreases with the increase ofR (Na2O/P2O5 mole ratio), and changes its sign from positive to negative at the value ofR near unity. In the composition range fromR=0.7 toR=1.4, where the thermal conductivity increases with the increase ofR, the composition dependence of thermal conductivity can be explained by the composition dependences of density and of compressibility. The residual water in the phosphates on the ultraphosphate side of composition seems to have some large effect on the thermal conductivity.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 187 (1986), S. 1087-1095 
    ISSN: 0025-116X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: Solvent effects on the tautomerism and polymerization of ethyl 3-oxo-pentenoate (1) were studied. Regression analysis of the tautomeric constant reveals that the equilibria depend on the polarity and hydrogen-bond donor acidity of the solvents. The polymerization was investigated in benzene and acetonitrile. In both solvents, the kinetic results do not meet the conventional model of radical polymerization.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 188 (1987), S. 371-377 
    ISSN: 0025-116X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: Ethyl 3-oxo-4-pentenoate (1) exhibits the coexistence of two tautomers, the ketonic and enolic form, and its tautomeric equilibrium shifts with the solvent. The monomer reactivity ratios for the radical copolymerization of 1 (M1) and styrene (M2) in various solvents were determined. There is a marked and a minor solvent effect on r1 and r2, respectively. Regression analysis of r1 with the solvatochromic parameters yields a fairly good linear relationship, taking into account three factors: polarity and hydrogen bond donating and accepting powers of the solvents.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 190 (1989), S. 1007-1014 
    ISSN: 0025-116X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: p-Aminostyrene (1, M1) and styrene (M2) were radically copolymerized at 60°C in various solvents. There is a significant solvent effect on monomer reactivity ratios, especially on r1, suggesting a specific interaction between the solvent and the polymer radical with the p-aminostyrene moiety at the terminal position. In order to clarify the solvent factor influencing the relative reactivity, the hydrogen-bond-accepting basicity of the solvent (β) was determined from enhanced UV shifts for 1 relative to N,N-dimethyl-p-aminostyrene. Regression analysis of r1 with the solvatochromic parameters revealed that β is the major factor responsible for r1-variations.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
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