Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Medicine
54 (2003), S. 321-341
ISSN:
0066-4219
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Medicine
Notes:
Abstract Observational studies provide overwhelming evidence that a low high-density lipoprotein (HDL)-cholesterol level increases the risk of coronary events, both in healthy subjects and in patients with coronary heart disease. Based on in vitro experiments, several mechanistic explanations for the atheroprotective function of HDL have been suggested. However, few of these were verified in vivo in humans or in experiments with transgenic animals. The HDL functions currently most widely held to account for the antiatherogenic effect include participation in reverse cholesterol transport, protection against endothelial dysfunction, and inhibition of oxidative stress. This review summarizes current views on the molecular mechanism underlying these atheroprotective effects of HDL.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.med.54.101601.152409
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