Electronic Resource
Springer
Journal of neural transmission
44 (1979), S. 287-295
ISSN:
1435-1463
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Dopamine (DA) sensitive adenylate cyclase activity was measured in homogenates of caudate nucleus and putamen from frozen brain of eight Parkinsonian patients and nine controls. In the control group, there was no difference in enzyme activity in respect to sex or age (21–77 years old). Caudate nucleus and putamen exhibited similar mean activity. In the Parkinsonian group, there was a significant decrease in both basal (by 50%) and DA stimulated (by 80%) activities compared with that of control group. This suggests that there may exist a functional disturbance in the postsynaptic (post-DA-nergic) region in the striatum of patients with Parkinson's disease; in addition, the decrease in basal as well as DA stimulated activity as measured in homogenates may not be the biochemical substrate for the hypothetical “denervation super-sensitivity” expected to occur in Parkinson's disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01250323
Permalink
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
