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  • Electronic Resource  (2)
  • 1985-1989  (2)
  • 1955-1959
  • 1986  (2)
  • Brain  (1)
  • GABA-B receptors  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Does pipecolic acid interact with the central GABA-ergic system? (1986)
    Springer
    Journal of neural transmission 67 (1986), S. 175-189 
    Details
    ISSN: 1435-1463
    Keywords: Pipecolic acid ; GABA ; Micro-iontophoresis ; GABA-B receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several previous studies have suggested a strong GABA-mimetic action of the endogenous brain imino acid, L-pipecolic acid (L-PA). In the present study, these observations were evaluated using electrophysiological and neurochemical methods. In contrast to published data our electrophysiological studies on rat cortical neuronesin situ showed only a weak, but bicuculline-sensitive depressant action of L-PA on cortical neurones. Furthermore, L-PA proved to have no affinity for any of the three components of the GABA-benzodiazepine-chloride channel receptor complex. However, using a modification of published methods a weak affinity for the GABA-B receptor site was demonstrated (IC50=1.8×10−3 M). L-PA showed no anticonvulsive activity in several tests; in particular, it did not protect mice from seizures induced by inhibition of L-glutamate-1-decarboxylase (EC 4.1.1.15: GAD). L-PA had a very weak action on brain GABA levels of mice, and did not modify the rate of GABA synthesis. In conclusion, these results are not compatible with a strongin vivo interaction between L-PA and GABA-mediated inhibitory transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243346
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of androgen administration on the structure and function of the brain-pituitary-gonad axis of sexually immature platyfish, Xiphophorus maculatus (1986)
    Springer
    Cell & tissue research 245 (1986), S. 519-524 
    Details
    ISSN: 1432-0878
    Keywords: Brain ; Pituitary ; Gonad ; Androgens ; Platyfish, Xiphophorus maculatus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early-and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocytochemical evaluation, increases the number and activity of pituitary gonadotropes, stimulates the production of sperm and, thus, advances the age of sexual maturation over that dictated by the genome. We also show that 11-KT and T affect different LHRH-containing centers in the brain and have differential effects on rate and degree of sexual maturation, regardless of whether the hormones are administered to early or late-maturing genotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218552
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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