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  • Digitale Medien  (4)
  • 1990-1994  (4)
  • 1955-1959
  • 1992  (4)
  • Life and Medical Sciences  (2)
  • pancreas  (2)
  • supercritical fluid chromatography
Datenquelle
Materialart
  • Digitale Medien  (4)
Erscheinungszeitraum
  • 1990-1994  (4)
  • 1955-1959
Jahr
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma (1992)
    Springer
    Investigational new drugs 10 (1992), S. 205-209 
    Details
    ISSN: 1573-0646
    Schlagwort(e): phase II ; fazarabine ; adenocarcinoma ; pancreas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract We conducted a phase II evaluation of fazarabine 1.75–2.0 mg/m2hr over 72 hours every 28 days in 14 previously untreated patients with advanced adenocarcinoma of the pancreas. The intial dose was 1.75 mg/m2/hr in 10 patients, and 2.0 mg/m2hr in 4 patients. The dose was escalated in 8 patients, including all 4 who started at the higher dose level. Toxicity was unexpectedly mild. The median WBC nadir was 4.4 (range: 2.4–15.8)×103/μl, the median absolute neutrophil nadir was 3.2 (range: 0.9–13.0)×103/μl, and the median platelet count was 134.0 (range: 48.0–291.0)×103/μl. Gastrointestinal toxicity was generally mild. No major responses were seen, excluding, with 95% confidence, a response rate in excess of 20%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00877247
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma (1992)
    Springer
    Investigational new drugs 10 (1992), S. 313-316 
    Details
    ISSN: 1573-0646
    Schlagwort(e): phase II ; edatrexate ; adenocarcinoma ; pancreas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract We conducted a phase II evaluation of edatrexate in 17 previously untreated patients with advanced adenocarcinoma of the pancreas; 14 patients had at least one month of therapy. The initial dose was 80 mg/m2iv. Treatment was administered weekly for 5 weeks, then every other week. Toxicity was generally mild. The median WBC nadir was 5.4 (range 0.6–7.4)×103/μl, and the median platelet nadir was 164.0 (range 62.0–341.0)×103/μl. One patient died with sepsis and gastrointestinal bleeding associated with pancytopenia. Five patients had a mild rash. Nausea occurred in 6 patients, including 3 who had vomiting. In addition, 11 patients complained of vague malaise which seemed to begin within 24–48 hours after administration of edatrexate, and lasted for 2 to 3 days, resolving within 6 days of drug administration. Median survival was 85 days. Although 5 patients had stable disease, including one with relief of pain, no major responses were seen, excluding, with 95% confidence, a response rate in excess of 20%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00944187
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  • 3
    Digitale Medien
    Digitale Medien
    A multiplanar anatomic study of the cervical proximal nerve roots and spinal nerves (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 5 (1992), S. 433-440 
    Details
    ISSN: 0897-3806
    Schlagwort(e): anatomy ; spine ; sheath ; Life and Medical Sciences ; Miscellaneous Medical
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: An anatomic study focused on the proximal cervical spinal nerves has not been reported. Therefore, we dissected the cervical spinal nerves of three cadavers and examined stained sections in parasagittal and axial planes through the proximal cervical spinal nerves and root sheaths. These studies documented distinct segments of the spinal nerve which had not been completely described in the previous anatomic studies. The sheath originates from the dural sac as a common sleeve, divides into two sleeves, one containing the ventral root and one the dorsal root, and then distal to the dorsal root ganglion fuses again into one sleeve. A space, the interradicular cleft, separates the dorsal and ventral portions of the sleeve. The proximal segment of the spinal nerve proper distal to the dorsal root ganglion is composed of multiple small fascicles surrounded by a dense epineurium. The presence of an interradicular cleft in the cervical nerve root sheath and of fascicles in the cervical spinal nerve has significance for imaging of the cervical spinal nerves and for the pathogenesis of symptoms in cases of partial compression. © 1992 Wiley-Liss, Inc.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ca.980050603
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  • 4
    Digitale Medien
    Digitale Medien
    Dihydropyridine calcium antagonist modulates cholesterol metabolism and eicosanoid biosynthesis in vascular cells (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 48 (1992), S. 393-400 
    Details
    ISSN: 0730-2312
    Schlagwort(e): calcium channel blocker ; atherosclerosis ; LDL ; LDL-receptor ; vascular smooth muscle ; PGI2 ; cyclic AMP ; cyclooxygenase ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Recent clinical studies have shown that calcium channel blockers can retard and possibly reduce the angiographic progression of coronary artery disease. Calcium channel blockers also inhibit dietary-induced atherosclerosis in animal models of this disease. In this study, we delineate potential cellular and molecular mechanisms by which nicardipine, a dihydropyridine calcium antagonist, may alter lipoprotein and cholesterol trafficking, affect the regulatory signal transduction pathways involved in accelerating cholesteryl ester (CE) catabolism in vascular smooth muscle cells, and modulate cell-cell interactions of vascular and inflammatory cells. We demonstrate in arterial smooth muscle cells that nicardipine increases (1) LDL binding, uptake, and degradation, (2) RNA transcript levels for the LDL receptor, (3) CE catabolic activity, (4) PGI2 release, and (5) RNA transcript levels for cyclooxygenase. Furthermore, nicardipine blocked cytokine-induced monocyte adhesion to endothelial cells and smooth muscle cells. Taken together, these findings support the hypothesis that nicardipine may function as an anti-atherosclerotic agent by promoting CE catabolism and cholesterol clearance and by reducing monocyte adhesion to the activated endothelium.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcb.240480408
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