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  • Electronic Resource  (7)
  • 1990-1994  (7)
  • 1993  (7)
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  • Electronic Resource  (7)
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  • 1990-1994  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    Sub-gingival microflora in Macaca mulatta species of rhesus monkey (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Macaca mulatta species of rhesus monkey is one of several non-human primate (nhp) models for periodontal disease. This report presents the bacteriology of the gingival sulci in M. mulatta monkeys. Three sub-gingival sites (maxillary right central incisor, the disto-buccal of the mandibular left second molar and mesio-buccal of the mandibular right second molar) of 9 monkeys were evaluated clinically before scaling and 7 days after scaling. Plaque samples were obtained from sub-gingival sites before clinical examination and studied bacteriologically by dark field microscopy, selective and non-selective culture, and by primary phenotypic characterizations of culture isolates. Several gingival sites presented with mild gingival inflammation. Anaerobic and facultatively anaerobic bacteria were the predominant flora colonizing the gingival sulci. The major microbial groups were Haemophilus species (100% of sites; percentage of total anaerobic count (TAC); 21-51), Peptostreptococcus micros (89%, 7.5–29.5), Actinomyces sp. (85%, 7–27), Fusobacterium nucleatum (90%, 5–8), Actinobacillus actinomycetemcomitans (73%, 1.3–12), black-pigmented anaerobic rods (BPAR) (80%, 0.6–6.5) and oral streptococci (80%, 0.2–1.0). Microbial groups detected less often were Wolinella sp. (66%, 0–2.6), Capnocytophaga sp. (30%), Eikenella corrodens (4.7%, 0), Campylobacter sp. (28%, 0–0.1) and spirochetes (4.7%, 0–0.07). Seven days after gingival sites were scaled, the plaque score and indices for gingival inflammation declined significantly. The gingival flora after scaling were characterized by lower proportions of the Actinomyees sp., P. micros and BPAR; and increased proportions of the oral streptococci, relative to pre-scaling levels. The major microbial groups at scaled gingival sites were the Haemophilus sp., oral streptococci, F. nucleatum and A. actinomycetemcomitans. The mutual proportions of microbial groups varied non-significantly within gingival sites and between monkeys. In conclusion, the M. mulatta gingival sulci are colonized by microbial species that resemble putative pathogens of periodontal disease, and the composition and character of the gingival flora are similar to the gingival flora of other Old World monkey models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1993.tb01053.x
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  • 2
    Electronic Resource
    Electronic Resource
    New clinical diagnostic strategies based on pathogensis of disease (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pathogenesis of periodontal tissue destruction involves the orchestrated sequential activation of several components of the host response, each of which have the potential for providing diagnostic information regarding the health or disease status of the periodontium. These events include the bacterial triggering of serum components, the release of vasoactive compounds, the recruitment of inflammatory cells, the activation of phagocytes, the local secretion of immunoglobulins and inflammatory mediators, as well as connective tissue remodeling. For purposes of diagnosis, much attention has been directed toward the measurement of local levels of specific byproducts pathogenic process either within the tissues or in the adjacent crevicular fluid. These are site-directed assessments of the local concentration of these byproducts, and with the important exception of antibody levels, very few byproducts of the periodontal pathogenic process have been studied on a systemic level. However, since the risk associated with periodontal disease progression is primarily patient-based and secondarily site-based, there is an increasing need to identify patients at risk for intervention strategies. Furthermore, there are substantial data that periodontal diseases are specific infections that occur in an appropriately susceptible host. The expression of periodontal disease has a strong genetic component, which presumably defines the host's response thereby affecting susceptibility. For this reason, there is increased interest in defining those elements of the host response which result in susceptibility to disease. The ultimate objective of a diagnostic strategy is to identify patients who are potentially at risk for acquiring disease to enable preventive measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1993.tb02118.x
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  • 3
    Electronic Resource
    Electronic Resource
    An open trial of long-term therapy with lansoprazole in patients with peptic ulceration resistant to extended high-dose ranitidine treatment (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 7 (1993), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Forty-two patients with peptic ulceration of the duodenum, stomach or oesophagus, who had not responded to 3 or more months of high-dose treatment with ranitidine (450 or 600 mg/day), were treated with oral lansoprazole at 30–60 mg daily. In 40 patients (95.2%) the ulcers healed within 2–12 weeks. In the remaining 2 patients healing took several months but eventually all ulcers healed. After healing, 40 patients underwent long-term maintenance treatment with 30–60 mg lansoprazole daily for 1–3 years (continuing). During maintenance therapy with lansoprazole, no endoscopically verified relapses occurred when the drug was taken regularly. In 1 patient treatment had to be discontinued because of a drug-related colitis that disappeared soon after treatment had been stopped. There were no significant changes in routine laboratory tests in any patient. Basal serum gastrin concentrations, which were already elevated by the previous high-dose ranitidine treatment (125 ± 25 pg/ml), rose to four times the normal values after 4 weeks of treatment with lansoprazole (255 ± 65 pg/ml). Thereafter no further increases in basal serum gastrin concentrations were observed, even after 3 years of administration. The volume density of argyrophilic cells in the oxyntic mucosa increased slightly during lansoprazole treatment; until now no dysplasia of the enterochromaffin-like cells has been observed. In conclusion, 30–60 mg lansoprazole daily healed ranitidine-resistant peptic ulcers, and subsequent maintenance therapy with 30–60 mg lansoprazole daily was found to be highly effective and safe over the time observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1993.tb00589.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Nucleolar organizer regions and glycoprotein-hormone α-chain reaction as markers of malignancy in endocrine tumours of the pancreas (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 22 (1993), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The value of silver staining of nucleolar organizer regions (AgNORs) and human chorionic gonadotropin α-chain reaction (HCG-α) as markers of malignancy was investigated in 60 primary pancreatic endocrine tumours, 37 of which had metastasized at the time of surgery, and in one of which metastases developed 4 years after surgery. Assessment of AgNORs by digital image analysis revealed few but large AgNORs (mean number 2.5 ± 1.1; mean area ± in the 22 benign tumours and many but small AgNORs (mean number 5.1 ± 1.9, P〈0.05; mean ± 9 μm2. P〈0.01) in the malignant tumours. Quantification of the number of AgNORs per tumour cell AgNOR distribution score) showed that 96% (26/27) of tumours exhibiting at least 5% of cells with more six AgNORs per nucleolus showed metastases either at the time of diagnosis or up to 4 years after surgery. HCG-α immunoreactive cells were present in 25/38 (66%) malignant tumours and in 4/22 (18%) benign tumours. Combined evaluation of AgNOR distribution and HCG-α scores showed a high positive predictive value of 96% in cases with a raised AgNOR distribution score irrespective of the HCG-α status. A good negative predictive value (81%) was, however, only obtained if both parameters, AgNOR distribution and HCG-α scores, were negative. Thus, investigation of AgNORs HCG-α is helpful in predicting malignancy in a high percentage of pancreatic endocrine tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1993.tb00069.x
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  • 5
    Electronic Resource
    Electronic Resource
    Pseudoreticulocytosis in a patient with myelodysplasia (1993)
    Springer
    Annals of hematology 67 (1993), S. 127-128 
    Details
    ISSN: 1432-0584
    Keywords: Myelodysplastic syndrome ; Reticulocytes ; Erythrocyte abnormalities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with a myelodysplastic syndrome (MDS) and reticulocytosis of 〉50% in the absence of a correspondingly increased erythrocyte turnover is reported. Evaluation of the kinetics of erythrocyte turnover revealed a decreased erythrocyte life span of 44 days. From these data a prolongation of the reticulocyte maturation time to 〉20 days can be concluded. The patient's erythrocytes lacked the increase of mean corpuscular volume and a significant increase of erythrocyte enzymes that would be expected in marked reticulocytosis. This finding suggests that the reticulocytes represented not newly formed red blood cells, but “pseudoreticulocytes”, i.e., mature erythrocytes that retained their substantia reticulofilamentosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01701735
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  • 6
    Electronic Resource
    Electronic Resource
    Cytochromes P450 and drug resistance (1993)
    Springer
    Cytotechnology 12 (1993), S. 357-366 
    Details
    ISSN: 1573-0778
    Keywords: anticancer drugs ; cytochrome P450 ; drug resistance ; metabolic activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Cytochromes P450 are the key enzymes for activating and inactivating many drugs, in particular anticancer drugs. Therefore, individual expression levels of cytochromes P450 may play a crucial role in drug safety and drug efficacy. Overexpression of cytochrome P450 may yield rapid turnover and elimination of drugs before the target site was reached and any pharmacological effect is observed. Therefore, it may be vital to know the individual cytochrome P450 status in order to select the appropriate drug before drug resistance occurs. Expression levels and activity of cytochromes P450 depend on many different factors. These factors include tissue and organ specific expression, sex- and age-dependent expression, genetic differences yielding polymorphic forms, competitive inhibition or induction of cytochromes P450 due to multiple drug interaction, nutrition and diet. Genetically engineered test cells defined for cytochromes P450 are available for studying drugs for metabolic activation and for identifying the metabolically competent cytochrome P450 isoform.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00744673
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The Jason project experience and attitudes toward science as an enterprise and career (1993)
    Springer
    Journal of career development 20 (1993), S. 101-112 
    Details
    ISSN: 1573-3548
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02110342
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