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Hydrophobic vs coulombic interactions in the binding of steroidal polyamines to DNA (1996)

Muller, James G. ; Ng, Mabel M. P. ; Burrows, Cynthia J.

Chicester [u.a.] : Wiley-Blackwell

Journal of Molecular Recognition 9 (1996), S. 143-148

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Details

ISSN: 0952-3499

Schlagwort(e): polyamines ; steroids ; DNA ; DNA binding ; hydrophobic effects ; Coulombic interactions ; guanidinium ion ; Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin

Notizen: Seven new steroidal polyamines derived from bile acids, either lithocholic or deoxycholic acid, have been studied as DNA-binding agents using four complimentary methods: an ethidium displacement assay, observed changes in the thermal denaturation of poly[d(AT)], effects on hyperchromicity of DNA, and circular dichroism. In addition, modelling studies were conducted to examine the electrostatic surface potential of the polycations. The results point to a key role for a large hydrophobic surface area on the steroid in addition to the Coulombic attraction by ammonium and guanidinium groups on the steroid interacting with the polyphosphate backbone.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

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