ISSN:
1434-4726
Keywords:
Epidermal growth factor
;
Epidermal growth factor receptor
;
Transforming growth factor-alpha Human fetal inner ear
;
Development
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The expression of epidermal growth factor (EGF), EGF receptor and transforming growth factor (TGF)-alpha was analyzed in the human fetal inner ear using immuno-histochemical methods. EGF receptor was observed only in 9.5-week-old fetal vestibular epithelia. In 14- and 16-week-old fetuses, EGF receptor could not be detected. TGF-alpha was observed strongly in the 9- and 11-week-old vestibular epithelia, whereas only trace amounts were detectable in the 14- and 16-week-old vestibular epithelia. These findings suggest that EGF and TGF-alpha probably have a mitogenic effect in the sensory epithelia of the fetal inner ear, especially at early stages of development.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00179956
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