ISSN:
1573-6776
Source:
Springer Online Journal Archives 1860-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary The relationship between solventogenesis, heat shock, and DNA topology in Clostridium acetobutylicum was investigated by inhibiting DNA gyrase in vivo by high concentrations of novobiocin. Primer extension and Northern blot analyses revealed that expression of genes required for solventogenesis and heat shock response was induced in the presence of this drug, whereas the transcription rate of acidogenic genes decreased, suggesting a role for DNA supercoiling as a signal for onset of solventogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00129345
Permalink