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  • Electronic Resource  (5)
  • 1995-1999  (5)
  • 1960-1964
  • 1997  (5)
  • 1
    ISSN: 1432-0851
    Keywords: Key words Alveolar macrophages ; Tumoricidal activity ; PBL ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  It has been reported that the in vitro development of tumoricidal function in alveolar macrophages from lung cancer patients is reduced significantly when compared to that in peripheral blood monocytes from the same patients or alveolar macrophages from control patients. In the present investigation, a method for potentiating the development of tumoricidal function in alveolar macrophages from lung cancer patients is described. This method, which relies on priming the macrophages with purified, allogeneic peripheral blood lymphocytes from normal donors, could not be demonstrated when autologous lymphocytes from lung cancer patients were used in the priming coculture. The augmentation of tumoricidal function appears to be mediated by one or more soluble factors, since supernatants from cocultures of alveolar macrophages and allogeneic peripheral blood lymphocytes could enhance the cytotoxic function of freshly obtained alveolar macrophages. Furthermore, it appears that NK cells are necessary for this effect, since depletion of CD56+/CD57+ cells from allogeneic lymphocytes eliminated their capacity to enhance alveolar macrophage cytotoxic function. The augmentation of cytotoxic function elicited in alveolar macrophages by this method was not associated with changes in the secretion of tumor necrosis factor α, or interleukin 1β.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0851
    Keywords: Key words Alveolar macrophages ; Tumoricidal activity ; PBL ; Interleukin-6 ; Lung cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Previous studies have demonstrated that alveolar macrophages from lung cancer patients are impaired in their ability to develop tumoricidal function when stimulated by activators such as interferon γ + lipopolysaccharide. However, these same macrophages have been shown to develop significant tumoricidal function when precultured with macrophage-depleted allogeneic peripheral blood lymphocytes from normal donors, an effect that was lost by the elimination of natural killer cells from the allogeneic lymphocyte population. In the present study, the effect of each activation condition on the expression of mRNA for interleukin-1α (IL-1α), IL-1β, tumor necrosis factor α (TNFα) and IL-6 was determined using reverse transcription/polymerase chain reaction. The results show that the non-permissive activation condition is associated with the expression of mRNA for IL-6 while the permissive activation condition is not. Antibodies against IL-6 were subsequently shown to permit the development of tumoricidal function in alveolar macrophages stimulated with interferon γ + lipopolysaccharide while IL-6 protein was shown to inhibit the stimulatory action of allogeneic lymphocytes on the development of tumoricidal function in the same alveolar macrophages. Neither the permissive (i.e. allogeneic lymphocyte stimulation) nor the non-permissive (i.e. interferon γ + lipopolysaccharide) activation condition had any effect on the capacity of alveolar macrophages from lung cancer patients to express mRNA for IL-1α, IL-1β or TNFα. These results show that IL-6 can regulate the ability of alveolar macrophages from lung cancer patients to be stimulated by interferon γ + lipopolysaccharide to develop significant tumoricidal function. They also show that allogeneic lymphocytes have the capacity to down-regulate IL-6 mRNA synthesis by alveolar macrophages thereby permitting the development and/or expression of macrophage tumoricidal function.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 65 (1997), S. 341-348 
    ISSN: 1432-0630
    Keywords: PACS: 33.50.D; 68.35.G; 78.66; 87.22
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Aus Bisacrylaten wurden durch photoinduzierte Vernetzung in der isotropen Phase zweikomponentige Netzwerke synthetisiert. Bei allen Systemen wurde als eine Komponente ein Bisacrylat verwendet, das eine flüssigkristalline Phase bilden kann, und als zweite Komponente ein Bisacrylat, das dazu nicht in der Lage ist. Die isotrope Komponente wurde hinsichtlich ihrer Größe, Geometrie und Polarität variiert. Für alle Systeme wurden mittels einer Wärmeflußkalorimetrie (DSC) Phasendiagramme der Monomermischungen erstellt. Das Phasenverhalten der Systeme zeigt eine Abhängigkeit vom Schmelzpunkt und der chemischen Struktur der isotropen Zweitkomponente. Die Vernetzungstemperatur wurde so gewählt, dafß die Vernetzung in der isotropen Phase 10 °C über der Phasenllbergangstemperatur erfolgte. Die Reaktionskinetik wurde aus den Photopolymerisationsenthalpien mittels eines für photochemische Vernetzungen modifizierten DSC-Gerätes untersucht. Die Zeitabhängigkeit des Umsatzes und der Gesamtumsatz an Acrylatbindungen wurden aus den DSC-Kurven ermittelt. Der Gesamtumsatz hängt nicht von der Reaktionstemperatur und der Struktur der Monomeren ab und liegt je nach Zusammensetzung füralle Systeme zwischen 53 und 71%. Die Zeitabhängigkeit des Umsatzes hingegen wird von der Struktur des nicht flüssigkristallinen Comonomeren beeinflufßt.
    Notes: Two-component networks of diacrylate monomers were synthesized by photoinduced polymerization in the isotropic phase. In all systems one component was a liquid-crystalline diacrylate, whereas the second component was a non-liquid-crystalline diacrylate, which was varied in size, geometry and polarity. The phase behaviour of the monomer mixtures has been analysed by differential scanning calorimetry (DSC). It is influenced by the melting point and the structure of the non-liquid-crystalline component. All samples were cross-linked in the isotropic phase 10°C above the phase transition temperature and a modified differential scanning calorimeter was used to investigate the enthalpies of photopolymerization. The final value and the time dependence of the conversion of acrylate double bonds were calculated from the DSC curves. The final degree of conversion of the acrylate double bonds was between 53 and 71% for all samples, whereas no significant dependence of the degree of conversion on the chemical structure of the monomers or the reaction temperature has been found. In contrast, the time dependence of the conversion was influenced by the chemical structure of the non-liquid-crystalline component.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die Struktur von Duromeren aus zwei in der isotropen Phase photochemisch vernetzten Bisacrylaten wurde anhand von Klein- und Weitwinkelröntgenuntersuchungen charakterisiert. Bei allen Systemen konnte eine Komponente eine flüssigkristalline Phase bilden, während die andere Komponente keine flüssigkristalline Phase besaß und in ihrer chemischen Struktur (Größe, Geometrie und Polarität) variiert wurde. Die Streuprofile der einkomponentigen Netzwerke im Kleinwinkelbereich zeigen Inhomogenitaten der Elektronendichte von einigen zehn Nanometem. Fur die zweikomponentigen Duromeren wird kein zusatzlicher Streubeitrag gefunden, der durch Zusammensetzungsinhomogenitaten verursacht wird. Dies ist ein Hinweis dafur, daB wahrend der photochemisch induzierten Vernetzungsreaktion keine Phasenseparation auftritt. Dieses Bild einer einphasigen amorphen Struktur wird durch Streuexperimente im Weitwinkelbereich bestatigt. Die Streuprofile der einkomponentigen Duromeren zeigen ein breites Maximum, dessen korrespondierende charakteristische Lange mit der GroBe und Geometrie der Monomeren korreliert ist. Auch fur die zweikomponentigen Netzwerke wird nur eine charakteristische Lange gefunden, die entsprechend der Zusammensetzung zwischen denen der einkomponentigen Duromeren liegt. Die Strukturuntersuchungen ergeben auch keinen Hinweis auf die Bildung einer flussigkristallinen Phase wahrend der Vernetzung.
    Notes: The structure of single- and two-component networks of diacrylate monomers which were synthesized by photoinduced polymerization in the isotropic phase has been investigated by small- and wide-angle X-ray scattering. In all systems one component was a liquid-crystalline diacrylate whereas the second component was non-liquid-crystalline. The chemical structure (size, geometry, and polarity) of the second component was varied. For the single-component networks the scattering profiles in the small-angle regime reveal inhomogeneities of the electron density of the order of some ten nanometers. For the two-component networks no additional scattering contribution due to composition inhomogeneities has been found. This is an evidence that no phase separation occurs during the photoinduced cross-linking of the thermosets. This picture of an amorphous single-phase structure is supported by the scattering profiles in the wide-angle regime. For the single-component networks a broad maximum is found, the corresponding characteristic length of which can be correlated with the structure of the monomers. For the two-component networks also only one characteristic length is found which shifts with composition between the length of the single-component thermosets. By both methods no indication for the development of a liquid-crystalline phase during network formation has been revealed.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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