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  • Electronic Resource  (21)
  • 2000-2004  (21)
  • 2004  (21)
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  • Electronic Resource  (21)
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  • 2000-2004  (21)
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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  This study explores the predictive value for live birth following tubal reconstructive surgery of the ‘Hull and Rutherford’ (H&R) classification system.Design  Retrospective cohort study.Setting  Tertiary infertility referral service, University of Bristol.Population  Infertile women younger than 40 years with tubal damage undergoing tubal surgery.Methods  Women (n= 192) were grouped according to three severity grades of disease based on the H&R classification. Essentially, the main features of grade I tubal damage were filmy adhesions, whereas grades II and III referred to unilateral severe damage and bilateral severe damage, respectively. Standard surgical techniques were employed. Pregnancy and live birth rates were calculated and compared using time-specific univariate Kaplan–Maier curves and multivariate Cox's regression analysis.Main outcome measures  Pregnancy, ectopic and live birth within three years of surgery.Results  A significant trend towards higher ectopic pregnancy rates (P 〈 0.001) with increasing severity of tubal damage was noted, but not miscarriage rates. Univariate analysis revealed significant differences in the live birth rates of 69%, 48% and 9% for grades I, II and III, respectively. Multivariate analysis (controlling for age, duration of and primary infertility) confirmed these differences to be significant with risk ratios of 13.7 (95% CI: 4.49–41.9) and 6.54 (95% CI: 2.48–17.24) for grades I and II disease, respectively, compared with grade III disease, used as the reference.Conclusions  The H&R classification is a simple classification system that is able to distinguish women into three distinct groups giving a favourable, fair and poor prognosis for live birth following tubal surgery.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0009-6407
    Source: Cambridge Journals Digital Archives
    Topics: History , Theology and Religious Studies
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 20 (2004), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The motivation to eat in humans is a complex process influenced by intrinsic mechanisms relating to the hunger and satiety cascade, and extrinsic mechanisms based on the appetitive incentive value of individual foods, which can themselves induce desire. This study was designed to investigate the neural basis of these two factors contributing to the control of motivation to eat within the same experimental design using positron emission tomography. Using a novel counterbalanced approach, participants were scanned in two separate sessions, once after fasting and once after food intake, in which they imagined themselves in a restaurant and considered a number of items on a menu, and were asked to choose their most preferred. All items were tailored to each individual and varied in their incentive value. No actual foods were presented. In response to a hungry state, increased activation was shown in the hypothalamus, amygdala and insula cortex as predicted, as well as the medulla, striatum and anterior cingulate cortex. Satiety, in contrast, was associated with increased activation in the lateral orbitofrontal and temporal cortex. Only activity in the vicinity of the amygdala and orbitofrontal cortex was observed in response to the processing of extrinsic appetitive incentive information. These results suggest that the contributions of intrinsic homeostatic influences, and extrinsic incentive factors to the motivation to eat, are somewhat dissociable neurally, with areas of convergence in the amygdala and orbitofrontal cortex. The findings of this study have implications for research into the underlying mechanisms of eating disorders.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Circadian rhythms in mammals depend on the properties of cells in the suprachiasmatic nucleus (SCN). The retino-recipient core of the mouse SCN is characterized by vasoactive intestinal peptide (VIP) neurons. Expression within the SCN of VPAC2, a VIP receptor, is required for circadian rhythmicity. Using transgenic mice with β-galactosidase as a marker for VPAC2, we have phenotyped VPAC2-expressing cells within the SCN and investigated expression of the VPAC2 marker at sites previously shown to receive VIP-containing SCN efferents. In situ hybridization and immunohistochemistry demonstrated identical distributions for VPAC2 mRNA and β-galactosidase and coexpression of the two signals in the SCN. Double-label confocal immunofluorescence identified β-galactosidase in 32% of the VIP and 31% of the calretinin neurons in the SCN core. Of the arginine-vasopressin neurons that characterize the SCN shell, 45% expressed β-galactosidase. In contrast, this marker was not apparent in astrocytes within the SCN core or shell. Cell bodies containing β-galactosidase were detected at sites reportedly receiving VIP-containing SCN efferents, including the subparaventricular zone and lateral septum and the anteroventral periventricular, preoptic suprachiasmatic, medial preoptic and paraventricular hypothalamic nuclei. The detection of a marker for VPAC2 expression in the SCN in almost one-third of the VIP and calretinin core neurons and nearly half of the arginine-vasopressin shell neurons and also in cell bodies at sites receiving VIP-immunoreactive projections from the SCN indicates that VPAC2 may contribute to autoregulation and/or coupling within the SCN core and to the control of the SCN shell and sites distal to this nucleus.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Huntington's disease (HD) is a fatal neurodegenerative disease caused by a CAG repeat expansion coding for an expanded polyglutamine tract in the huntingtin protein. Dendritic abnormalities occur in human HD patients and in several transgenic mouse models of the disease. In this study, we examine, for the first time, dendrite and spine pathology in the R6/1 mouse model of HD, which mimics neurodegeneration seen in human HD. Enriching the environment of HD transgenic mice delays the onset of symptoms, so we also examine the effects of enrichment on dendrite pathology. Golgi-impregnated tissue from symptomatic R6/1 HD mice reveals a decrease in dendritic spine density and dendritic spine length in striatal medium spiny neurons and cortical pyramidal neurons. HD also causes a specific reduction in the proportion of bifurcated dendritic spines on basal dendrites of cortical pyramidal neurons. No differences in soma size, recurving distal dendrites, or dendritic branching were observed. Although home-cage environmental enrichment from 1 to 8 months of age increases spine density in wild-type mice, it has no effect on the spine pathology in HD mice. These results show that dendritic spine pathology in R6/1 HD mice resembles degenerative changes seen in human HD and in other transgenic mouse models of the disease. We thus provide further evidence that the HD mutation disrupts the connectivity in both neostriatum and cerebral cortex, which will contribute to motor and cognitive disease symptoms. Furthermore, we demonstrate that Huntington's disease pathology interferes with the normal plastic response of dendritic spines to environmental enrichment.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The purpose of this study was to examine the responses of peak torque (PT), mean power output (MP), mechanomyographic (MMG) and electromyographic (EMG) amplitude and mean power frequency (MPF) of the vastus lateralis (VL), rectus femoris (RF), and vastus medialis (VM) in males and females during maximal, concentric isokinetic muscle actions. Subjects performed maximal leg extensions at 60° s−1, 120° s−1, 180° s−1, 240° s−1, 300° s−1, 360° s−1, 420° s−1, and 480° s−1. No gender differences were obser-ved, but there were muscle-specific differences for the patterns of MMG MPF, EMG amplitude, and EMG MPF. The MP and MMG amplitude increased to 180–240° s−1, plateaued, and then decreased to 480° s−1. MMG MPF for the VL and VM remained unchanged to 300° s−1, but then increased to 480° s−1. The EMG amplitude for the RF and EMG MPF for the VL decreased across velocity. Overall, these findings indicated that there were muscle-specific, velocity-related differences in the associations among motor control strategies (EMG amplitude and MPF) and the mechanical aspects of isokinetic muscular activity (MMG amplitude and MPF).
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1751-8369
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Geosciences
    Notes: Although the diet of walrus (Odobenus rosmarus) is considered varied, records of walrus consuming marine birds are rare in the published literature. In 2001 and 2002 we observed walrus foraging on adult thick-billed murres (Uria lomvia) at Coats Island in Nunavut, Canada. Approximately 46% of the attacks on murres were successful, and as many as 67 murres may have been killed in one day in August 2002. All soft parts of the murres were sucked out, with carcasses of only bones, feathers and skin left floating on the water. The extent to which predation on seabirds by walrus occurs across the eastern Arctic is unknown, but it could represent an important source of mortality for murres at some breeding colonies.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Bingley : Emerald
    Library review 53 (2004), S. 228-235 
    ISSN: 0024-2535
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Information Science and Librarianship
    Notes: This study compared the five subscale scores and total scale scores of the Library Anxiety Scale from 135 Caucasian-American and 45 African-American graduate students. Findings indicated that the Caucasian-American sample reported significantly higher levels of library anxiety associated with three of the five subscales than did the African-American sample. A canonical discriminant analysis also revealed significant differences between the two racial groups, with Caucasian-American graduate students reporting significantly higher levels of library anxiety associated with the same three subscales than their African-American counterparts. These findings suggest that race appears to be a predictor of library anxiety levels. The implications of the findings on academic library services and future research are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Journal of small business & enterprise development 11 (2004), S. 315-328 
    ISSN: 1462-6004
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The small business sector of the UK economy is extremely important and the government expends considerable resources in providing support services for this sector. This paper investigated the reasons why SMEs move from traditional commerce to e-commerce, the efficacy of the support services and the barriers encountered by SMEs adopting e-commerce. The research methodology involved literature review and interviews with SMEs' owner-managers and a UK Online business adviser. It was found that at least two "e-commerce stars" used by the government to promote its support services had in fact not used those services. The historical relationship problems between Business Link and SMEs were still causing problems. Cost was not seen as an inhibitor to adopting e-commerce. Some evidence was emerging that e-commerce may be able to save failing or struggling businesses. Other unexpected outcomes were that e-commerce had social benefits for SMEs' owners in reducing working hours yet still increased sales.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background.  Numerous studies have employed the Delphi technique to seek expert opinion about aspects of clinical practice. When researching literature on the Delphi technique, however, we discovered discrepancies in its application, and a lack of detail when reporting design, administration, and analysis methods. Such lack of specificity hinders the replicability and assessment of the clinical and cultural validity and reliability of Delphi studies.Aim.  The aim of this paper is to detail the practical application of the Delphi technique as a culturally and clinically valid means of accessing expert opinion on the importance of clinical criteria.Methods.  Reference is made to a bicultural New Zealand mental health nursing clinical indicator study that employed a three-round reactive Delphi survey. Equal proportions of Maori and non-Maori nurses (n = 20) and consumers (n = 10) rated the importance of 91 clinical indicator statements for the achievement of professional practice standards. Additional statements (n = 21) suggested by Delphi participants in round 1 were included in subsequent rounds. In round 2, participants explained the rating they applied to statements that had not reached consensus in round 1, and summarized responses were provided to participants in round 3. Consensus was considered to have been achieved if 85% of round 3 ratings lay within a 2-point bracket on the 5-point Likert-scale overall, or in one of the Maori nurse, non-Maori nurse, or consumer groups. A mean rating of 4·5 after round 3 was set as the importance threshold.Findings.  Consensus occurred overall on 75 statements, and within groups on another 24. Most statements (n = 86) reached the importance benchmark.Conclusions.  When rigorous methods of participant selection, group composition, participant feedback, and determination of consensus and importance are employed, the Delphi technique is a reliable, cost-effective means of obtaining and prioritizing experts judgements.
    Type of Medium: Electronic Resource
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