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  • Electronic Resource  (76)
  • 2020-2024
  • 2005-2009  (37)
  • 1920-1924  (11)
  • 1910-1914  (28)
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  • Electronic Resource  (76)
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  • 1
    Electronic Resource
    Electronic Resource
    AB 5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP (2006)
    [s.l.] : Nature Publishing Group
    Nature 443 (2006), S. 548-552 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] AB5 toxins are produced by pathogenic bacteria and consist of enzymatic A subunits that corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake into the target cell. AB5 toxins include the Shiga, cholera and pertussis toxins and a recently ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05124
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  • 2
    Electronic Resource
    Electronic Resource
    Gene expression in the dinoflagellate Karenia brevis: Analysis of an expressed sequence tag (EST) library and development of an oligonucleotide microarray (2005)
    Oxford, UK : Blackwell Science Inc
    The @journal of eukaryotic microbiology 52 (2005), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Karenia brevis (Davis) is a unicellular dinoflagellate responsible for nearly annual “red tides” in the Gulf of Mexico. Insight into the molecular mechanisms that control growth, toxicity, and adaptive mechanisms in K. brevis is critical to understanding the formation and persistence of these toxic blooms. However, little information is available on the molecular biology K. brevis. Therefore, we constructed a cDNA library from which to gain insight into its expressed genome and to develop tools for studying gene expression. Large-scale sequencing of 9728 clones yielded 7001 high-quality expressed sequence tags (ESTs) for further analysis. The highest expressed gene accounts for only 1% of the total ESTs. Approximately 29% of ESTs were found to have homology to known sequences in other organisms after BLASTx similarity comparisons to the Genbank nonredundant database (p〈10−4). Using a minimum identity of 95% within a 50-bp region of overlap, the 7001 ESTs were assembled into 5054 contigs. Of the 5054 contigs, 4399 contained only a single sequence. Of those containing 〉2 ESTs, approximately 40% displayed single nucleotide polymorphisms, suggesting the presence of multiple gene copies in this haploid organism. Gene-specific 60-mer oligonucleotides were then designed for each of the 5054 contigs using a Parcel clustering package, version 2.2.8 (Agilent). The resulting oligonucleotides and controls were printed on glass slides to yield an 8000 feature array using inkjet printing technology (Agilent). The 8000 features included 5054 unique features and 2946 secondary probes. Validation experiments to assess system noise, reproducibility, log ratio accuracy, and differential gene expression are underway using Agilent Feature Extraction tools and Rosetta Luminator Gene Expression Analysis software.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.2005.05202003_1_49.x
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  • 3
    Electronic Resource
    Electronic Resource
    Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 93 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 2-Amino-4,5,6,7-tetrahydrobenzo(β)thiophen-3-yl 4-chlorophenylmethanone (T62) is a member of a group of allosteric modulators of adenosine A1 receptors tested in animal models of neuropathic pain to increase the efficacy of adenosine. To determine its mechanisms at the level of receptor-G-protein activation, the present studies examined the effect of T62 on A1-stimulated [35S]guanosine-5′-O-(γ-thio)-triphosphate ([35S]GTPγS) binding in brain membranes, and by [35S]GTPγS autoradiography using the A1 agonist, phenylisopropyladenosine (PIA), to activate G-proteins. In hippocampal membranes, T62 increased both basal and PIA-stimulated [35S]GTPγS binding. The effect of T62 was non-competitive in nature, since it increased the maximal effect of PIA, with no effect on agonist potency. GTPγS saturation analysis showed that T62 increased the number of G-proteins activated by agonist but had no effect on the affinity of activated G-proteins for GTPγS. [35S]GTPγS autoradiography showed that the neuroanatomical localization of T62-stimulated [35S]GTPγS binding was identical to that of PIA-stimulated activity. The increase in PIA-stimulated activity by T62 varied between brain regions, with areas of lower A1 activation producing the largest percent modulation by T62. These results suggest a mechanism of allosteric modulators to increase the number of activated G-proteins per receptor, and provide a neuroanatomical basis for understanding potential therapeutic effects of such drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03044.x
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  • 4
    Electronic Resource
    Electronic Resource
    α-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 94 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Adult male unanesthetized rats, reared on a diet enriched in both α-linolenic acid (α-LNA) and docosahexaenoic acid (DHA), were infused intravenously for 5 min with [1-14C]α-LNA. Timed arterial samples were collected until the animals were killed at 5 min and the brain was removed after microwaving. Plasma and brain lipid concentrations and radioactivities were measured. Within plasma lipids, 〉 99% of radioactivity was in the form of unchanged [1-14C]α-LNA. Eighty-six per cent of brain radioactivity at 5 min was present as β-oxidation products, whereas the remainder was mainly in ‘stable’ phospholipid or triglyceride as α-LNA or DHA. Equations derived from kinetic modeling demonstrated that unesterified unlabeled α-LNA rapidly enters brain from plasma, but that its incorporation into brain phospholipid and triglyceride, as in the form of synthesized DHA, is ≤ 0.2% of the amount that enters the brain. Thus, in rats fed a diet containing large amounts of both α-LNA and DHA, the α-LNA that enters brain from plasma largely undergoes β-oxidation, and is not an appreciable source of DHA within brain phospholipids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03258.x
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  • 5
    Electronic Resource
    Electronic Resource
    Motives and Communibiology's Texts: Whose Motives+ (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Communication theory 15 (2005), S. 0 
    Details
    ISSN: 1468-2885
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Media Resources and Communication Sciences, Journalism , Psychology
    Notes: The motive analysis included in Nelson's (2004) textual critique of the writings regarding communibiology is examined and found erroneous. It is suggested that the claim that traditional genre theories are contradicted by this analysis is not justified. The motives for communibiological texts alleged by Nelson are seen as preempted by the (conscious or nonconscious) motives of the critic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-2885.2005.tb00345.x
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  • 6
    Electronic Resource
    Electronic Resource
    Prevention of Case-Hardening by Copper Plating (1924)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 16 (1924), S. 611-613 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50174a032
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  • 7
    Electronic Resource
    Electronic Resource
    THULIUM. (1910)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 32 (1910), S. 517-518 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01922a007
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  • 8
    Electronic Resource
    Electronic Resource
    BASIC NITRATE OF YTTRIUM. (1910)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 32 (1910), S. 873-879 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01925a004
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  • 9
    Electronic Resource
    Electronic Resource
    YTTRIUM POTASSIUM OXALATE. (1911)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 33 (1911), S. 488-492 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02217a006
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  • 10
    Electronic Resource
    Electronic Resource
    A NEW METHOD FOR THE SEPARATION OF CERIUM. (1911)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 33 (1911), S. 1326-1330 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02221a005
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