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  • Electronic Resource  (3)
  • 2005-2009
  • 1995-1999  (3)
  • testosterone  (2)
  • ALDH2  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Association of aldehyde dehydrogenase with inheritance of NIDDM (1996)
    Springer
    Diabetologia 39 (1996), S. 1115-1118 
    Details
    ISSN: 1432-0428
    Keywords: Aldehyde dehydrogenase ; chlorpropamide alcohol flushing test ; diabetes mellitus ; diabetic retinopathy ; ALDH2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the influence of the mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype on the clinical features of diabetes, 212 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) (154 males and 58 females aged 17–83 years; mean age 58.2 years) were investigated. Genotyping of ALDH2 was performed by the polymerase chain reaction — restriction fragment length polymorphism (PCR-RFLP) method. The pattern of inheritance of diabetes and various clinical parameters was compared between active and inactive ALDH2 groups. Of the 212 subjects, 120 had active ALDH2 and 92 had inactive ALDH2. The percentage of patients with a diabetic mother was higher in the inactive ALDH2 group (32.6%) than in the active ALDH2 group (19.2%) (p〈0.05). The prevalence of proliferative retinopathy was lower in the inactive ALDH2 group than in the active ALDH2 group (p〈0.05). However, other clinical parameters showed no difference. We conclude that maternal inheritance of diabetes was common in the inactive ALDH2 group. The finding is suggestive of a relationship between alcohol intolerance and inheritance of diabetes. We speculate that the interaction between mitochondrial DNA and ALDH2 inactivity causes an increase of mitochondrial DNA mutations or deletions, thereby inducing the maternal inheritance of diabetes. The relationship of the ALDH2 genotype with proliferative retinopathy is interesting, because it resembles that of chlorpropamide alcohol flushing with severe diabetic retinopathy. The interaction of aldehyde dehydrogenase isoenzymes might have an aetiological role, since aldehyde dehydrogenase 1 plays an important part in oxidation of retinal to retinoic acid. However, the number of affected patients with proliferative retinopathy was small, hence, our result should be considered as a preliminary finding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400662
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reproduction related immunoglobulin changes in rainbow trout (1997)
    Springer
    Fish physiology and biochemistry 17 (1997), S. 415-421 
    Details
    ISSN: 1573-5168
    Keywords: fish ; trout ; reproduction ; seasonal changes ; immunoglobulin ; testosterone ; estradiol-17β ; 11-ketotestosterone ; water temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Annual changes in plasma immunoglobulin (IgM) levels were investigated in three strains of rainbow trout Oncorhynchus mykiss which have different spawning periods, i.e., September–October, November–December, and January, reared under constant water temperature and natural day length. Plasma IgM levels decreased during the spawning season in all strains tested. The IgM changes became reversed in response to significant increases in plasma testosterone (T) and estradiol-17β in females and T and 11-ketotestosterone in males. Though the IgM decline showed a connection with suppressed immunocompetence, since many mature fish caught fungal diseases, no clear differences were observed in the plasma IgM levels between infected and noninfected fish during the spawning season. Incidentally, plasma IgM levels in infection prone fish were higher than in noninfection prone fish prior to the spawning season, whereas coincident differences in the plasma steroid levels were observed. Immature fish reared under lower water temperatures showed lower IgM levels. The effect of water temperature may have to be considered when analyzing the defense mechanism during the spawning season in rainbow trout.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007795827112
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of steroid hormones on immunoglobulin M (IgM) in rainbow trout, Oncorhynchus mykiss (1999)
    Springer
    Fish physiology and biochemistry 20 (1999), S. 155-162 
    Details
    ISSN: 1573-5168
    Keywords: cortisol ; estradiol-17β ; 11-ketotestosterone ; mucus ; plasma ; testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The immunosuppressive effects of steroid hormones were evaluated as the response against implanted steroid hormones, cortisol (F), testosterone (T), estradiol-17β (E2), and 11- ketotestosterone (11-KT), in juvenile rainbow trout. In long term experiments (5 weeks), fish were given a single intraperitoneal implant of F or T. A clear suppressive effect of plasma IgM levels with F and T was not necessarily obtained, although mucus IgM levels were reduced corresponding to the elevated plasma steroid hormone levels. In short term experiments (1 week), intraperitoneal implantation of T, 11-KT and E2 suppressed plasma and mucus IgM levels, although the effects were not dose-dependent. When administered through diet, F and T caused a suppression of plasma IgM levels; F administration at both high and low dosages caused a significant decrease in plasma IgM levels, while only a high dose of T caused the suppression. These results suggest that sex steroid hormones, as well as F, have immunosuppressive functions in rainbow trout.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007799617597
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    Paper (German National Licenses)
    Fulltext
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