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  • Electronic Resource  (5)
  • 2005-2009  (4)
  • 1970-1974  (1)
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  • Electronic Resource  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Globular amyloid β-peptide1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 95 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Amyloid β-peptide (Aβ)1−42 oligomers have recently been discussed as intermediate toxic species in Alzheimer's disease (AD) pathology. Here we describe a new and highly stable Aβ1−42 oligomer species which can easily be prepared in vitro and is present in the brains of patients with AD and Aβ1−42-overproducing transgenic mice. Physicochemical characterization reveals a pure, highly water-soluble globular 60-kDa oligomer which we named ‘Aβ1−42 globulomer’. Our data indicate that Aβ1−42 globulomer is a persistent structural entity formed independently of the fibrillar aggregation pathway. It is a potent antigen in mice and rabbits eliciting generation of Aβ1−42 globulomer-specific antibodies that do not cross-react with amyloid precursor protein, Aβ1−40 and Aβ1−42 monomers and Aβ fibrils. Aβ1−42 globulomer binds specifically to dendritic processes of neurons but not glia in hippocampal cell cultures and completely blocks long-term potentiation in rat hippocampal slices. Our data suggest that Aβ1−42 globulomer represents a basic pathogenic structural principle also present to a minor extent in previously described oligomer preparations and that its formation is an early pathological event in AD. Selective neutralization of the Aβ globulomer structure epitope is expected to have a high potential for treatment of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03407.x
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  • 2
    Electronic Resource
    Electronic Resource
    Review of Wages of Wins: A Reply (2006)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Journal of quantitative analysis in sports 2 (2006), S. 4 
    Details
    ISSN: 1559-0410
    Source: Berkeley Electronic Press Academic Journals
    Topics: Sports Science
    Notes: We provide a response to Beech's review of The Wages of Wins: Taking Measure of the Many Myths in Modern Sport in this journal. Specifically we are responding to three misinterpretations and/or misstatements in the book review. At the end of each section we explain the process in which we reach our conclusions and where we differ with the reviewer's ascertations.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/jqas/vol2/iss4/4
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    V. Prelude to Intervention: Madagascar and the Failure of Anglo-French Diplomacy, 1890–1895 (1972)
    Cambridge : Cambridge University Press
    The @historical journal 15 (1972), S. 715-730 
    Details
    ISSN: 0018-246X
    Source: Cambridge Journals Digital Archives
    Topics: History
    Notes: The last decade of the nineteenth century brought to a climax Anglo-French tensions on many colonial issues. Generally overlooked in the roll-call of disputes which centred upon Egypt but extended to Newfoundland fisheries, Siam, and West Africa as well, is the position of Madagascar between the two powers at the commencement of the difficult decade. Madagascar warrants greater attention than it has received, for, with Egypt and Newfoundland, it became in 1891 and 1892 the central problem in colonial discussions between the two governments. On the side of France the issue left feelings of bad faith and broken promises which contributed to the strained tone of relations with Great Britain during the decade. This was all the more unfortunate since Madagascar was an issue apparently settled by the colonial arrangement of 5 August 1890 between the two powers. But the instrument which might have been expected to improve relations became instead another source of discord. Madagascar, at the heart of the agreement for France, presents therefore a striking and significant example of lost opportunity in colonial diplomacy. For the diplomatic failure led inevitably to a military solution to the problems confronting France on the Grand Isle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0018246X00003514
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Individuation: finding oneself in analysis – taking risks and making sacrifices (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    The @journal of analytical psychology 50 (2005), S. 0 
    Details
    ISSN: 1468-5922
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: Abstract:  This paper looks at some of the processes that are at work in finding oneself in analysis. It explores Jung's unique contribution to our thinking about the self and its dynamic of individuation. The author attempts to show how the Self, in its quest for consciousness, requires the surrendering of ego inflation—the narcissistic delusion that the ego is the self. A case is made for seeing analysis as an individuation process which offers the opportunity for experiences of a more authentic sense of oneself. Jung stated that individuation requires the ego to enter into service of the Self. For this to happen, the author argues that both patient and analyst must be prepared to make sacrifices and take risks. Using clinical examples, he illustrates that, although purposive, the Self can be experienced as violent and destructive if the ego is unable to facilitate its expression. This may result in an individuation crisis for both analyst and patient. The paper demonstrates how impasse in analysis can evoke the transcendent function, which also requires sacrifices to be made and risks to be taken for analysis to proceed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0021-8774.2005.00560.x
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  • 5
    Electronic Resource
    Electronic Resource
    Global analysis of protein phosphorylation in yeast (2005)
    [s.l.] : Nature Publishing Group
    Nature 438 (2005), S. 679-684 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Protein phosphorylation is estimated to affect 30% of the proteome and is a major regulatory mechanism that controls many basic cellular processes. Until recently, our biochemical understanding of protein phosphorylation on a global scale has been extremely limited; only one half of the yeast ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04187
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    Paper (German National Licenses)
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