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  • Electronic Resource  (21)
  • 2005-2009  (21)
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  • Electronic Resource  (21)
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  • 1
    Electronic Resource
    Electronic Resource
    Left Ventricular Epicardial Activation Increases Transmural Dispersion of Repolarization in Healthy, Long QT, and Dilated Cardiomyopathy Dogs (2005)
    350 Main Street , Malden , MA 02148-5018 , USA and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Pacing and clinical electrophysiology 28 (2005), S. 0 
    Details
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Benefits of cardiac resynchronization therapy (CRT) are well established. However, less is understood concerning its effects on myocardial repolarization and the potential proarrhythmic risk. Methods and Results: Healthy dogs (n = 8) were compared to a long QT interval (LQT) model (n = 8, induced by cesium chloride, CsCl) and a dilated cardiomyopathy with congestive heart failure (DCM-CHF, induced by rapid ventricular pacing, n = 5). Monophasic action potential (MAP) recordings were obtained from the subendocardium, midmyocardium, subepicardium, and the transmural dispersion of repolarization (TDR) was calculated. The QT interval and the interval from the peak to the end of the T wave (Tp-e) were measured. All these characteristics were compared during left ventricular epicardial (LV-Epi), right ventricular endocardial (RV-Endo), and biventricular (Bi-V) pacing. In healthy dogs, TDR prolonged to 37.54 ms for Bi-V pacing and to 47.16 ms for LV-Epi pacing as compared to 26.75 ms for RV-Endo pacing (P 〈 0.001), which was parallel to an augmentation in Tp-e interval (Bi-V pacing, 64.29 ms; LV-Epi pacing, 57.89 ms; RV-Endo pacing, 50.29 ms; P 〈 0.01). During CsCl exposure, Bi-V and LV-Epi pacing prolonged MAPD, TDR, and Tp-e interval as compared to RV-Endo pacing. The midmyocardial MAPD (276.30 ms vs 257.35 ms, P 〈 0.0001) and TDR (33.80 ms vs 27.58 ms, P=0.002) were significantly longer in DCM-CHF dogs than those in healthy dogs. LV-Epi and Bi-V pacing further prolonged the MAPD and TDR in this model. Conclusions: LV-Epi and Bi-V pacing result in prolongation of ventricular repolarization time, and increase of TDR accounted for a parallel augmentation of the Tp-e interval, which provides evidence that Tp-e interval accurately represents TDR. These effects are magnified in the LQT and DCM-CHF canine models in addition to their intrinsic transmural heterogeneity in the intact heart. This mechanism may contribute to the development of malignant ventricular arrhythmias, such as torsades de pointes (TdP) in congestive heart failure (CHF) patients treated with CRT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8159.2005.00218.x
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  • 2
    Electronic Resource
    Electronic Resource
    Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 44 (2005), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak of dengue-2 infections in Southern Taiwan. Results showed that virus load was not significantly different between patients with and without dengue hemorrhagic fever. Patients with dengue fever had higher IFN-γ levels, but patients with dengue hemorrhagic fever had significantly higher IL-10 levels. Further studies showed that patients with dengue hemorrhagic fever had a significantly lower T-bet than those with dengue fever, but GATA-3 mRNA expression in peripheral blood leukocytes was not significant difference between both groups. In conclusion, altered Th1 reaction as reflected by lower T-bet mRNA expression associated with higher IL-10 levels might be involved in the pathogenesis of dengue hemorrhagic fever.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsim.2004.11.012
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  • 3
    Electronic Resource
    Electronic Resource
    Design and fabrication of CAP scaffolds by indirect solid free form fabrication (2005)
    Bingley : Emerald
    Rapid prototyping journal 11 (2005), S. 312-318 
    Details
    ISSN: 1355-2546
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Purpose - To fabricate the self-hardening calcium phosphate composite scaffolds with controlled internal pore architectures using rapid prototyping (RP) techniques and investigate their in vitro bone tissue engineering responses. Design/methodology/approach - The three-dimensionally interconnected pores in scaffolds can facilitate sufficient supply of blood, oxygen and nutrients for the ingrowth of bone cells, tissue regeneration, and vascularization. It is essential for bone tissue engineering to provide an accurate control over the scaffolds material, porosity, and internal pore architectures. Negative image of scaffold was designed and epoxy resin molds were fabricated on sterolithography apparatus. Calcium phosphate cement slurry was cast in these molds. After self-hardening, the molds were removed by pyrolysis and the resulting scaffolds were obtained. Findings - Eight scaffolds with 54.45 percent porosity were tested on an Instron machine. The average compressive strength measured was 5.8±0.8?Mpa. Cytotoxicity and cell proliferation studies were conducted with rabbit osteoblast. Results showed that these scaffolds were non-toxic and displayed excellent cell growth during the 2 weeks of in vitro culture. Research limitations/implications - The resulting scaffolds inherited errors and defects from the molds, such as cracks and dimensional changes. Originality/value - The present method enhances the versatility of scaffold fabrication by RP. It is capable of reproducibly fabricating scaffolds from a variety of biomaterials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/13552540510623639
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  • 4
    Electronic Resource
    Electronic Resource
    Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 672-677 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The muscular dystrophies are a heterogeneous group of disorders for which there are currently no cures. Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant late-onset, progressive disease that generally presents in the fifth or sixth decade with dysphagia, ptosis and proximal limb ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1242
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  • 5
    Electronic Resource
    Electronic Resource
    Feedback Linearization of Hysteretic Thermoelastic Dynamics of Shape Memory Alloy Actuators with Phase Transformations (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 47-50 (June 2008), p. 69-72 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In the current paper, a macroscopic differential model for the hysteretic dynamics inshape memory alloy actuators is constructed by using the modified Landau theory of the first orderphase transformation. An intrinsic thermo-mechanical coupling is achieved by constructing the freeenergy as a function depends on both mechanical deformation and the material temperature. Bothshape memory and pseudoelastic effects are modeled. The hysteretic dynamics is linearized byintroducing another hysteresis loop via nonlinear feedback strategy, which cancels the original one
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.69.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation and Characterization of Porous Silica Obtained by Hydrochloric Acid Selective Leaching Metakaolinite (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 342-344 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Porous silica was prepared by selective leaching of metakaolinite with 20 mass% HCl solution.The metakaolinite was derived from the 1:1 layered structure clay mineral kaolinite by firing at 600°C for24 h. The characteristics of porous silica were studied. The content of Al2O3 in metakaolinite was sharplychanged from 45% to less than 2% after 2 h leaching. The maximum specific surface area of the leachedsample was about 350 m2/g. The average pore size is about 2 nm. The total pore volume is 0.3 ml/g. Thelayer structure of kaolinite and metakaolinite is responsible for forming micropores
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.342.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Optical Scattering Mechanisms of Functional Nano-Material Films on Transmission Display Screen (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 348-351 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this paper, the application of new functional nano-material films prayed on transmissiondisplay screen is studied. Optical properties, such as luminance gain and scattering angle, of the screensare measured to investigate the particle size effects on the properties. The results show that the opticalproperties of screen sprayed with nano-material film improve notably compared with those screens withfilms of conventional particle sizes. When the particle size is less than 100nm, the gain is high and theviewing angle low. With increasing particle sizes, the characteristics of screens vary with particle sizes. Inorder to solve the contradictory relationship between gain and viewing angle and to obtain screens withdesirable optical properties, suitable nano-particle sizes ranging from 400nm to 700nm should be chosenfor the spraying film. The scattering mechanisms between nano-particles and light are also discussed
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.348.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    The Spectroscopy Characterization of Kaolinite-Organic Intercalation Materials (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 1362-1365 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Kaolinite/formamide intercalation materials are characterized using X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), Raman spectroscopy and 1H magic anglespinning nuclear magnetic resonance spectroscopy (1H MAS NMR). The d(001) spacing ofkaolinite treated with formamide is 1.020nm, which is larger than that of the original clay. The 1HMAS NMR graphs show that the proton chemical shifts of the inner hydroxyl and inner surfacehydroxyl of kaolinte are δ-1.3 and δ2.4 respectively. After formamide intercalation, the protonpeaks of the inner surface hydroxyls shifted to high-field with δ2.3, the proton peak of the innerhydroxyl shifted to δ-0.3 toward low-field. In the hydroxyl stretching vibration region of Ramanspectrum, the formamide intercalation resulted in the decrease of the intensities of kaolinite innersurface hydroxyl bands at 3699cm-1,3682cm-1, 3665cm-1 and 3642cm-1, and the appearance ofadditional bands at 3610cm-1,3628cm-1. In the NH stretching region of FT-IR spectrum, two bandsare observed at 3336cm-1 and 3466cm-1 corresponding to the two types of the hydrogen bondsbetween formamide and kaolinite. In the carboxyl stretching region, an additional band at 1667cm-1is assigned to C=O group that bonded to the inner surface hydroxyl of kaolinite
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.1362.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Water Debinding for Zirconia Powder Injection Molding (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 732-735 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Water debinding is an important debinding technique for ceramic injection molding. Howevercracks or blisters usually generate during water extraction. In this paper, two types of multi-componentbinder systems were studied: (1) a major fraction of polyethylene glycol (PEG), and a minor fraction ofpolyvinyl butyra (PVB) and other additives. (2) a major fraction of PEG, and a minor fraction ofpolymethyl methacrylate (PMMA) and other additives. Mechanism of defects generation wasinvestigated, and PEGs with various molecular weights were introduced to avoid cracks or blisters duringthe process. Further more, the compatibilities of PEG/PVB and PEG/PMMA were studied. The resultsshowed that PEG and PMMA exhibited better compatibility, with the feedstock more homogeneous andsintered ceramic parts higher strength
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.732.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Preparation and Characterization of Kaolinite-Glucose Intercalation Compound (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 368-372 (Feb. 2008), p. 1068-1070 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Kaolinite-glucose intercalation compound was synthesized by the intercalation of polarorganic big molecule dodecylamine and then displaced by glucose in the layer of kaolinite. XRD, FT-IR,TG and DSC were used to study the reaction process and the characters of the products. The resultsindicated that the basal spacing of kaolinite increased to 2.280 nm from 0.717 nm, and the hydrogenbonds were formed between dodecylamine NH and kaolinite Si-O after dodecylamine intercalation.Kaolinite-dodecylamine intercalation compound was stable below 295 °C. After displacement reactionby glucose, the basal spacing of kaolinite increased to 3.364 nm, and the intercalation rate reached 87%,the hydrogen bonds were formed between glucose C=O and kaolinite inner surface hydroxyl.Kaolinite-glucose intercalation compound was stable below 302 °C
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.368-372.1068.pdf
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