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  • Electronic Resource  (3)
  • 2000-2004  (1)
  • 1995-1999  (2)
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  • Electronic Resource  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    THE ROLE OF DYNAMICS IN ENZYME ACTIVITY (2003)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 32 (2003), S. 69-92 
    Details
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract Although protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, or ligand binding may have different dynamical dependencies from those for enzymes, and enzymes with large turnover numbers may have different dynamical dependencies from those that turn over more slowly. The timescale differences between the fastest anharmonic fluctuations and the barrier-crossing rate point to the need to develop methods to resolve the range of motions present in enzymes on different time- and lengthscales.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biophys.32.110601.142445
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A reply (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 50 (1995), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1995.tb06082.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Congestive Heart Failure with Tetralogy of Fallot Relieved by an Aortopulmonary Shunt (1997)
    Springer
    Pediatric cardiology 18 (1997), S. 381 -384 
    Details
    ISSN: 1432-1971
    Keywords: Key words: Tetralogy of Fallot — Congestive heart failure — Aortopulmonary shunt — Hypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Congestive heart failure occurring in unoperated patients with otherwise uncomplicated tetralogy of Fallot (TF) is rare. We report the case of a boy who was first diagnosed as having TF when he presented at age 3 years with hypoxia and heart failure. Heart failure improved following an aortopulmonary shunt. We attributed his heart failure to cardiomyopathy associated with severe hypoxia. We believe that this report is the first one that attributes heart failure to hypoxia in an unoperated patient with tetralogy of Fallot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002469900206
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    Paper (German National Licenses)
    Fulltext
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