ISSN:
1434-9949
Keywords:
Heat Shock Protein
;
Gene Transcription
;
Systemic Lupus Erythematosus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In the present study, we show the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in peripheral blood mononuclear cells (PBMC) of individuals with active systemic lupus erythematosus (SLE) by nuclear run-on transcription assay. For quantification analysis of hsp 70 gene transcription, we first found more than ten times of the enhanced transcription of hsp 70 gene in PBMC of individuals with active SLE, as compared to normal healthy subjects or patients with bronchial asthma as controls. Our observation suggests that heat shock proteins may be produced during an active immune response in individuals with active systemic lupus erythematosus and is involved in lupus-related change of possible essential function in PBMC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02031966
Permalink
