ISSN:
1432-0584
Keywords:
Key words B-cell lymphoma
;
Hemophagocytic syndrome
;
CD34-selection
;
PBSCT
;
Autologous GVHD
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 56-year-old man who presented with persistent high fever and abdominal pain was diagnosed as having a B-cell lymphoma associated with hemophagocytic syndrome (B-LAHS). As post-remission therapy, the patient was treated with high-dose chemoradiotherapy followed by infusion of autologous CD34+ cells that had been isolated from the peripheral blood buffy coat. Cyclosporin and interferon (IFN)-γ were administered to induce autologous graft-versus-host disease (GVHD). Hematopoietic recovery promptly occurred and skin GVHD developed on day 26 after CD34+ cell transplantation. The patient has been in complete remission without therapy for 20 months since transplant. Autologous CD34+ cell transplantation in combination with induction of autologous GVHD may be efficacious in obtaining a cure for B-LAHS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002770000157
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