ISSN:
1432-1106
Keywords:
Axons
;
Phospholipids
;
Cholesterol
;
Synaptosomes
;
Cere-bellum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Three distinct phospholipid patterns occurred in the mitochondrial subcellular fractions: a) myelin, b) axonal-synaptosomal and c) mitochondrial. Axonal and synaptosomal fractions were found to be very similar in phospholipid and cholesterol composition. In all submitochondrial fractions cholesterol, phosphatidyl serine and sphingomyelin occurred in the relatively constant molar ratio of 1.0∶0.18∶0.11. The phospholipid patterns reported in this paper correspond well to others published for synaptosomes and “synaptic membranes” from mammalian sources as well as axonal membranes from invertebrate sources. However, morphological analysis has indicated that axonal as well as synaptosomal fractions contained significant amounts of microsomes and abundant membranes of undetermined origin which must also be considered when attempting morphological-biochemical correlations. Attention was given to the possible functional and chemical similarity of axonal and synaptosomal membranes other than that portion presumably specialized for chemical transmission, and to the difficulty of establishing the lipid pattern of the “true synaptic membrane” in presently available preparations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00234281
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