ISSN:
1432-1238
Keywords:
Keywords Burns
;
Oxidative stress
;
Antioxidants
;
Vitamin C
;
Trace elements
;
Carotenoids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: To evaluate oxidative stress resulting from major burns in humans.¶Design: Prospective clinical study with control group.¶Setting: Mechanically ventilated adult patients admitted with more than 30 % total burn surface area.¶Patients and participants: 20 patients with a mean body surface burned area of 54 %.¶Measurements and results: The oxidative stress evaluation was based on measurements of trace elements, vitamins, antioxidant enzymatic activity and end-products of lipid peroxidation. During the first 5 days after injury burn patients exhibit a decrease in selenium and antioxidant vitamins (C, β-carotene, lycopene) and an increase in lipid peroxidation products (TBARS).¶Conclusion: Our results suggest that major burn is associated with oxidative stress during the 5 days after the initial injury, as demonstrated by a simultaneous decrease in antioxidant vitamins and a large increase in TBARS.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001340051250
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